<b><i>Introduction:</i></b> Ingrown toenails are one of the common nail problems generally occurs in the big toe area and most often occurs during productive ages. Treatment of ingrowing toenail can be chosen based on the clinical condition of the patient. Nonoperative therapy is not effective in advanced cases in terms of the severity. Improper handling will cause recurrence in this case. <b><i>Case Presentation:</i></b> Six of 8 patients had the ingrown toenail recurrence previously treated using the nail avulsion (onychectomy) without matricectomy. One patient was reported to have hemophilia as comorbidity. The other one had pincer nail associated with inflammatory and degenerative processes. Most patients were at modified Mozena grades III and IV ingrown toenail. Post therapy evaluation revealed no recurrence in all patients. <b><i>Conclusions:</i></b> Combination of wedge resection with matricectomy using electrocautery can be applied as therapy for recurrent ingrown toenail.

<p>Latar Belakang: Psoriasis adalah penyakit autoimun dengan dasar genetik dan dicetuskan oleh berbagai faktor di antaranya stresor fisik, stresor kimia dan paparan bahan-bahan kimia. Pembentukan radikal bebas dalam tubuh dapat dihambat oleh zinc. Tujuan: Untuk mengetahui kadar zinc serum penderita psoriasis. Metode : Penelitian analitik komparatif numerik dengan rancangan penelitian potong lintang. Sampel terdiri dari 10 orang penderita psoriasis dan 10 orang kontrol. Analisis sampel serum darah untuk pemeriksaan kadar zinc menggunakan inductively couple plasma-mass spectrometry (ICP-AES). Analisis statistik menggunakan uji independent sample T-Test dan bermakna jika nilai p&lt;0,05.Hasil: Kadar zinc serum penderita psoriasis lebih rendah dibandingkan kontrol (p = 0,02).</p><p>Background: Psoriasis is an autoimmune disease with a genetic basis and triggered by several factors such as chemical agent. The formation of free radicals can be inhibited by zinc. Objective: To determine serum zinc level among psoriasis patients. Methods: An analysis with numerical comparative, coss-sectional study design. Samples were 10 psoriasis and 10 non psoriasis patients. Analysis of blood serum samples for zinc levels used inductively couple plasma-mass spectrometry (ICP-AES). Statistical analysis used independent sample T-test with significant value p&lt;0.05. Results: The serum zinc level was significantly lower in psoriasis patients compared to non psoriasis group (p = 0,02).Tutik Rahayu, Eka Putra W, Marsita Endy D, Rina Diana,</p>

Background: Keloid is a fibroproliferative disease in which its etiology remains unknown. Various therapy modalities have been improved, but none of them gives a satisfying outcome. Pirfenidone (PFD) is a commonly used drug in pulmonary fibrotic diseases, which has an anti-fibrotic effect. 5-fluorouracil (5-FU) is one of the keloid therapy choices that has long been used. This study aimed to investigate PFD's effect and its combination with 5-FU on fibroblast proliferation and collagen deposition.Methods: This experimental study using post only control group design was conducted by comparing PFD in various doses (0.5, 1.0, 1.5, 2.0, 3.0 mg/ml) and its combination with 5-FU on keloid fibroblast proliferation and collagen deposition. We used MTT (3-[4,5-dimethylthiazol-2-yl}-2,5diphenyl tetrazolium bromide) and Sirius Red assays to measure the fibroblast proliferation and collagen deposition, respectively. The statistical analysis used one-way ANOVA with p-value p<0.05 was considered significant.Results: The combination of PFD 3.0 mg/ml + 5-FU 1.0 mg/ml had more significant effect on inhibiting fibroblast proliferation as well as decreasing collagen deposition compared to 5-FU only (p<0.043). PFD 1.0 mg/ml + 5-FU 1 mg/ml as well as PFD 1.5 mg/ml+ 5-FU 1 mg/ml are more effective in inhibiting fibroblast proliferation and lowering collagen deposition than PFD only with p values of <0.001 and <0.000, respectively.Conclusion: In general, PFD, as well as 5-FU, are effective in inhibiting fibroblast proliferation and decreasing collagen deposition in keloid. However, the combination of both has a better effect compared to PFD or 5-FU monotherapy.

Nevus comedonicus is an extremely rare adnexal hamartoma of pilosebaceous apparatus, with approximately 200 cases reported in the literature so far. It appears as cluster of adjacent honeycomb-like dillated follicular openings with firm pigmented keratin plugs resembling comedones.The comedones oftentimes arranged in linear pattern paralled to Blaschko’s lines. We report a case of a 5-year-old boy with open brown to black comedones in a linear pattern localized on the back of the left thigh that appearing since birth. Pain, itch and discharge were not obtain. There were some episodes of infection, due to manual removal done by his mother which left some hypertrophic scars. Dermoscopic examination revealed the distinctive pattern consisting of pigmented, sharply demarcated keratin plugs of 1-3 mm in diameter, some open pores, multiple structurless, various shades of brown homogenous circular areas surrounding the plugs. Histopathological examination showed an aggregation of dilated follicular infundibulum with laminated keratinous material plugging. This case report prove that dermoscopy examination, a simple non-invasive diagnostic tool is very helpful in diagnosing nevus comedonicus. We recommend this tool to differentiate the diagnosis of other rare epidermal nevi while histopathological examination should be performed only in uncertain cases.

Anestesi tumescent adalah anestesi lokal dengan cara infiltrasi lidokain dan epinefrin yang diencerkansehingga area pembedahan menjadi sembab, tegang, dan bengkak. Pada awalnya anestesi ini dikembangkanuntuk bedah sedot lemak yang terdiri dari 4 komponen utama yaitu zat anestesi, epinefrin, larutan fisiologisnatrirum klorida 0,9% dan Natrium bikarbonat. Dengan anestesi ini dosis lidokain dapat ditingkatkan beberapakali lipat sampai dengan 35mg/kg dari dosis maksimal sebelumnya yaitu 5mg/kg sehingga didapatkan areatindakan yang lebih luas. Selain itu didapatkan area operasi yang bersih karena perdarahan minimal, keamananyang tinggi, risiko infeksi yang rendah, pasien dalam kondisi sadar sehingga memungkinkan perubahanposisi pasien intraoperasi, serta efek hidrodiseksi jaringan yang memudahkan penyedotan lemak. Keuntunganlain cara anestesi ini yaitu mencegah kehilangan serta menjaga keseimbangan cairan tubuh karena normalsalin yang digunakan sebagai pengencer dapat sebagai hidrasi pasca-operasi. Anestesi ini dapat digunakanpada berbagai tindakan non dermatologi maupun dermatologi yaitu pada bedah sedot lemak, dermabrasi,kuretase kelenjar minyak aksila pada bromhidrosis, eksisi tumor, blok anastesi, dan beberapa tindakan lainnya.Kata kunci: anestesi, tumescent, bedah sedot lemak.