No abstract

Hydrazone is an imine-derived compound that has various biological activities such as anticancer, antitumor, antioxidant, antimicrobial, and antidepressant. Antioxidants play an important role in removing oxidants and preventing cell damage and the toxicity of a compound is one of the parameters in drug discovery, especially anticancer. In this work, a hydrazone, 1-(4-chlorobenzylidene)-2-phenylhydrazine has been synthesized under microwave irradiation and evaluated for its antioxidant activity by DPPH assay. The toxicity of this compound was evaluated by Brine Shrimp Lethality Test (BSLT) for pre-screening of anticancer drugs. The compound was elucidated for its structure using UV-Vis, FTIR, GC-MS, 1D, and 2D NMR spectrometers. Based on the toxicological evaluation using BSLT, the synthesized compound possessed a highly toxic with LC50 value of 0.018 μg/mL and has strong antioxidant activity with IC50 value of 41.33 μg/mL. These suggest that the synthesized hydrazone compound is a potential compound in the development of antioxidant and anticancer drugs.

Secara budaya masyarakat indonesia tidak memiliki budaya melek huruf yang tinggi. Tingkat melek budaya masyarakat indonesia terburuk kedua dari 65 negara yang diperiksa di dunia. Indonesia menempati urutan ke 64 dari 65 negara. Pada beberapa penelitian, posisi baca siswa indonesia dalam rangka 57 dari 65 negara yang di periksa, Indonesia telah mengalami tingkat melek darurat. budaya literasi harus dipaksa dan terbiasa menjadi budaya. Budaya literasi ini akan mempengaruhi kualitas pendidikan dan sumber daya manusia yang di produksi. Masalah rendahnya tingkat melek huruf terutama di jalur pendidikan tidak hanya tanggung jawab pemerintah. Semua ini membutuhkan sinergi yang serius dan berkelanjutan, baik di keluarga, sekolah, universitas, bahkan masyarakat untuk menyadarinya. Literasi menjadi harus menjadi budaya utama. Karena membaca dapat meningkatkan kualitas dalam berfikir seperti pepatah mengatakan “membaca adalah jendela ilmu” dengan membaca wawasan menjadi luas.

Hydrazones have been reported for various biological activities, including their scavenging radical activity as antioxidants. The presence of azomethine group (-NHN=CH-) makes this compound one of the important classes in many synthetic products. In this study, ortho and meta-positions of chloro-substituted hydrazones have been synthesized through condensation reaction between substituted benzaldehydes and phenylhydrazine under microwave irradiation. The structure of the synthesized compounds was confirmed by UV, FTIR, 1H-NMR, and GC-MS spectroscopic data while antioxidant activity was tested by the DPPH method. Hydrazone compounds were successfully synthesized in good yield and short-time reaction. The results of in vitro antioxidant activity assay showed that chlorohydrazone have very good antioxidant activity, whereas meta has better activity than ortho-position with IC50 value of 25.8 and 57 µg/mL respectively. The results demonstrated that these active compounds may use to support as a decent stand for further investigation in a way to ascertain innovative antioxidant medicines.