The purpose of this study is to analyze the influence of supervision and motivation on employee performance with employee commitment as an intervening variable. Respondents in this study were taken using the census method. The total population was 97 people obtained from filling out questionnaires distributed to 97 respondents. The data analysis technique used was Partial Least Square (PLS).The results of this study showed that supervision did not affect employee commitment, motivation affected employee commitment, supervision affected employee performance, motivation affected employee performance, employee commitment affected employee performance, supervision affected employee performance through employee commitment as a variable intervening, and motivation affected employee performance through employee commitment as an intervening variable.The results of this study indicated that supervision and motivation had influence on employee performance with employee commitment as an intervening variable. It is suggueted to the management to provide input and improvement to employees in doing work to increase employee motivation, with increased motivation can increase employee commitment and carry out work responsibly towards Muaradua General Hospital, South Ogan Komering Ulu Regency. Keywords :Supervision, Motivation, Employee Commitment, Employee performance.