Objective. Vascular cognitive impairment (VCI) is an entity associated with vascular damage of the brain resulting in cognitive dysfunction of a wide spectrum from mild cognitive impairment to vascular dementia. The quality of life (QL) of patients with VCI is poorly understood especially in patients with mild VCI. The aim of the study was to estimate medical factors influencing QL of patients with mild VCI.Methods. We investigated 90 patients with mild VCI (52 men and 38 women, mean age 67.5 ± 10.6 years) that had score 3 on Riesberg Global Deterioration Scale, a MMSE score of more than 24 and focal or diffuse vascular changes on MRI (0.5 T scan). We used the EQ-5D scale for QL assessment and comprehensive neuropsychological battery for evaluation of several domains of cognitive functions: verbal and visual memory, attention, language, abstraction, visuospatial and executive functions, praxis. For assessment of motor dysfunction we used Tinetti balance and mobility scale (TBMS) and scale of pseudobulbar syndrome and for measure of affective disorders-Beck depression inventory (BDI).Results. EQ-5D values correlated to a degree of cognitive dysfunction measured with digit symbol constitution test (r = 0.34, p < 0.05), Rey-Osterrieth complex figure test (r = 0.68, p < 0.01), block design test (r = 0.33, p < 0,05), grammatical and phonetic associations number in verbal fluency tests (p < 0.05) categories achieved and number of perseverative responses on Wisconsin Card Sorting Test (r = 0.30, p < 0.05, r = − 0.39, p < 0.01). There were no correlations between EQ-5D values and total severity of cognitive dysfunction. We also found that EQ-5D values correlated to TBMS score (r = 0.51, p < 0.05), pseudobulbar scale score (r = − 0.4, p < 0.05) and severity of mood disturbances, assessed with BDI (r = − 0.42, p < 0,001).Conclusion. These results suggest that QL of patients with mild VCI correlates with the severity of executive and visuo-spatial cognitive dysfunction, postural instability and gait disorder, pseudobulbar syndrome and mood disturbances.