Herbal medicine as a traditional medicine based on local wisdom in the Covid 19 pandemic is the alternative for the community to keep the health of the body. Specific drugs for the cure of Covid-19 disease have also not been found yet so the death of Covid-19 patients remainsat anytime. In this case this study aims to know the content of secondary metabolite compounds and radical scavenger activity of “kayu jawa” (L. coromandelica) leaf steeping and “Salam” (S. polyanthum) leaves from Southeast Sulawesi as well as their rational combination based on the radical scavenger activity of DPPH (2,2-difenyl-1-picrilhydrazil). The analysis of the content of secondary metabolite compounds in the steeping of DKJ (Daun Kayu Jawa) and DS (Daun Salam) is applied by phytochemical method and radical scavenger activity is determined by the DPPH method. The main focus of steeping is determined by the approach of the picnometer. The combination of DKJ and DS is made each with 6 variations based on the IC50 steeping value, then converted in the form of weight (grams) of DKJ and DS powder so that 36 combinations are obtained. The result of phytochemical analysis of DKJ and DS steeping showed the presence of flavonoids, saponins and polyphenols, except tannins only exist in the steeping of DS. The radical scavenger activity of DKJ and DS steeping showed IC50 values of 408.95 ± 0.075 µg/mL and 259.05 ± 0.092 µg/mL. The combination that showed the highest DPPH radical scavenger activity of 88.050.03% occurred in the combination of E1 with a ratio of 2IC50 DK: 1/8IC50DS (1,089: 0.128) grams. DPPH radical scavenger activity approaching 50% occurs in the combination of A2 and B1 with a ratio of 1/8IC50 DKJ: ¼IC50DS (0.068:0.256) grams and ¼IC50 DKJ: 1/8IC50DS (0.136:0.128) grams with values of (49.11 0.04) % and (52.87  0.05) % respectively.

Telah dilakukan penelitian Fitokimia dan Uji Aktivitas Antioksidan Ekstrak Etanol Daun Soni (Dillenia serrata Thunb) dengan Metode DPPH. Penelitian ini bertujuan untuk mengetahui senyawa metabolit sekunder dan aktivitas antioksidan dari ekstrak Ekstrak Etanol Daun Soni (Dillenia serrata Thunb).Senyawa metabolit sekunder yang terkandung dalam ekstrak etanol daun Daun Soni ditentukan dengan metode fitokimia, sedangkan aktivitas antioksidannya dengan metode DPPH. Daun soni yang digunakan adalah daun soni kering yang telah dihaluskan. Sebanyak 500g daun soni dimaserasi selama 3x24 jam dengan pelarut etanol 96% yang sudah didestilasi. Ekstrak kemudian dikumpulkan dan dipekatkan sehingga diperoleh ekstrak kental sebanyak 145 g. Ekstrak di uji fitokimia dan antioksidan. Hasil uji fitokimia menunjukkan bahwa ekstrak etanol daun soni mengandung alkaloid, flavonoid, steroid, saponin, polifenol, dan tanin.Ekstrak etanol daunsonimemiliki aktivitas antioksidan kuat dengan nilai IC50  sebesar 15.3048 ± 0.2365 ppm.