This study was aimed to determine the fear of COVID-19 and related factors in patients. This study was conducted with 639 patients who were admitted to the emergency department. Data were collected using the sociodemographic characteristics form, Fear of COVID-19 scale (FCV-19S). The data were evaluated with Student’s t-test to compare two groups and one-way ANOVA and post hoc Tukey’s honestly significant difference (HSD) more than two groups. Multiple linear regression analysis was used to determine the relationship between dependent and independent variables. The mean age of patients was 46.12 ± 17.02, 53.4% were male, 70.7% were married, 42.4% had a chronic disease, 18.3% stated that they had symptoms of COVID-19, and 38.0% stated that they experienced economic difficulties due to COVID-19. The COVID-19 fear scores were significantly higher in 57 ages and over, female, had lung disease, had COVID-19 symptoms, and had children. Having a lung disease, female gender, and fear of COVID-19 were statistically significantly correlated with FCV-19S scores. As a result, it was determined that patients admitted to the emergency department had fear of COVID-19. Further research is recommended to support our study findings. As an emergency nurse, strategies must be developed to cope with these fears.