Massive Online Open Course (MOOC) is a web-based interactive online learning medium that allows users to take its courses and get completion certificates. The number of MOOC users does not run straight with the total rate of course completion. This is due to various user reasons, such as just to search for specific materials or sources without completing the course. Until now, there are still few studies that discuss the continuance intention to use MOOC. Thus, this study aims to evaluate a user’s desire to keep learning using MOOC in zenius.net with a combination of technology attractiveness theory and expectation confirmation model. A quantitative study was conducted by distributing questionnaires to 164 respondents. The result shows that a user's desire to keep learning through MOOC was directly influenced by the level of user satisfaction. User satisfaction is directly affected by perceived benefits as well as the user's evaluation of his or her expectations on MOOC. The benefits felt by users are directly affected by Task Attractiveness and the user's evaluation of his or her expectations on MOOC. While the user's evaluation of his expectations on MOOC is directly influenced by the three factors of Technology Attractiveness, namely Task Attractiveness, Social Attractive-ness, and Physical Attractiveness.

Social responsibility is one factor that causes a person or group of people to identify him/herself as a part of palce and community. Research shows that Research shows that being unaware of their social responsibility is the cause of people’s ignorance towards their social surrounding. The purpose of this study was to determine the effect of social responsibility training in increasing social responsibility of a group of Senior Resident students in the dormitory of university “X”. The study was differentiate in four stages: Base line (pre- test), social responsibility training, action plan and posttest. This study involved 13 Senior Residents and 106 first year dormitory residents. Quantitative (questionnaires) and qualitative data (interview) was used to measure the training effect.The results of this study indicate an increase in Social Responsibility and Place Attachment in participants, although it is not significant, but data shows an increase of social responsibility in three times measurement. The implication of this study is the importance of sustainability of training and action plan to obtain significant results.

Staphylococcus aureus is a common component of skin flora of healthy adults. However, it can cause serious infections such as bloodstream infections, pneumonia, or bone and joint infections. Methicillin-resistant Staphylococcus aureus (MRSA) is known to cause hospital- (HA-MRSA) and community-acquired (CA-MRSA) infections worldwide. Asia is reported to have highest prevalence rates of HA-MRSA and CA-MRSA. As there were very less number of epidemiological studies being done in Malaysia, this study aimed to determine the prevalence of MRSA infection among the healthcare undergraduates who will be engaging with patients soon. We analyzed nasal swabs of students from a private medical institution in Klang Valley, Malaysia. Methicillin-resistance was accessed by sensitivity to the Oxacillin and Cefoxitin disks. In a total of 151 healthcare undergraduates, 117 of them were found positive for Staphylococcus aureus. Among the latter, 21 samples (13.9%) were resistant to Oxacillin and Cefoxitin. Our data shows significant high percentage of MRSA infection and therefore prevention strategies for MRSA need to be developed for the healthcare students before they engage with patients in clinic setting. Keywords: MRSA, nasal swab, healthcare undergraduates, Oxacillin.

Introduction: Abnormalities in glucose metabolism in diabetic patients may lead to an increased risk of certain cancers. Epidemiological studies and meta-analysis have shown that factors such as gender, age, obesity, and insulin resistance are related to cancer incidence. The anti-p53 antibody is a known cancer marker due to tumor-associated p53 accumulation. Many studies have aimed to unravel the link between diabetes and cancer. Here, we aimed to elucidate the impact of diabetes on malignancies by analyzing anti-p53 antibody in sera of type 2 diabetes mellitus (T2DM) patients. Materials and Methods: We conducted an observational study with a cross-sectional design. A total of 149 subjects comprised of 78 T2DM patients (32 with cancer risk and 46 subjects without cancer risk), 51 T2DM patients with cancer, and 20 healthy subjects as controls from multisites. The anti-p53 antibody was measured by enzyme-linked immunosorbent assay, while HbA1c was measured using the NGSP standardized method. Results: We observed an 8.3-fold (p<0.05) increase of anti-p53 antibody in the sera of T2DM patients and a 24-fold increase (p<0.001) in T2DM patients with cancer compared to healthy subjects. The anti-p53 antibodies significantly increased almost three times (p<0.05) in T2DM patients with cancer (0.72 U/mL±0.20) compared to T2DM patients (0.25 U/mL±0.05). Meanwhile, this antibody was almost undetectable in healthy subjects as a control group (0.03 U/ mL±0.03). The anti-p53 antibody level was higher in T2DM with cancer risk patients. However, we did not find a significant difference for it in T2DM without cancer risk patients (0.19 U/mL±0.03) and T2DM with cancer risk patients (0.29 U/mL±0.08). Multivariate regression analysis showed that T2DM with cancer was the only one independent factor (beta=0.218, p=0.019) that could predict the increase of anti-p53 antibody, controlled by age, gender, BMI, DM duration, and HbA1c. Conclusion: Our results showed that anti-p53 antibody almost not detected in healthy subjects, but 8.3-fold increase in the sera of T2DM patients and 24-fold increase in T2DM patients with cancer. Therefore, this biomarker provides new information which explains the link between diabetes and cancer.

We have synthesized two 1,4-dihydropyridine derivatives via one-pot three-component reaction. The reactions were catalyzed by copper(I) iodide nanoparticles with crystallite size of 78.4 nm. Formations of cyclocondensation products were confirmed by Fourier Transform Infrared (FTIR), UV-Vis and Gas Chromatography-Mass Spectrometry (GC-MS) spectra.