The genus Etlingera is a tropical perennial plant of the ginger family, Zingiberaceae, and is commonly used as a natural healing remedy due to its medicinal properties including anti-inflammatory, antibacterial, antifungal and anticancer properties. This study has focused on the use of Etlingera corneri crude extract as a treatment to examine the effects on MCF-7 breast cancer cell growth and proliferation. The plant extracts from both the inflorescence and rhizome (0-2000 µg/mL) were screened for cytotoxicity and reactive oxygen species (ROS) profiles in these cells. Following treatments, responses were monitored for 24 hours by MTT and dihydroethidium (DHE) 96-well plate assays. Etlingera corneri concentrations of between 15.6 and 2000 µg/mL significantly reduced the viability of MCF-7 breast cancer cell growth and proliferation. However, there were no significant effects on cell viability when treated with the rhizome extract of E. corneri. In spite of the different responses for cell viability, dose dependent increases of ROS production were apparent for both extracts. This may suggest that cell death responses are not directly signalled by ROS production with the inflorescence extract from E. corneri, warranting further studies of the mechanisms involved.