The modern market of drugs off ers a wide range of disinfectants. However, the constant use of the same drugs contributes to the development of resistance in the microfl ora and reduces the quality of activities. In this regard to develop eff ective measures to combat and prevent infectious diseases, it is necessary to periodically monitor the activity of disinfectants used in the enterprise. The purpose of the researches was to study the bactericidal eff ect of disinfectants on the microfl ora of poultry enterprises. The researches have been carried out at the Siberian Scientifi c and Research Institute of Poultry Farming – a branch of the Federal State Budgetary Scientifi c Institution “Omsk Agrarian Scientifi c Center”. The activity of 8 disinfectants to 37 test cultures isolated from poultry farms of diff erent productivity trends and species of poultry (chickens, turkeys, quails) has been tested. It has been found as a result of the conducted research that the most expressed bactericidal eff ect on gram-positive and gram-negative microorganisms were complex disinfectants, which included glutaraldehyde in combination with quaternary ammonium compounds. Thus, 1 % solutions of Gludesive and Viroshield provided the death of all test cultures, Dinovis Ultra and TN-4+ – 92 and 84 % of cultures. The disinfecting activity of Mirosan drug and formalin was most expressed for gram-positive microfl ora, among gram-negative microfl ora resistance was registered in 25–75 % and 25–50 % of cultures, respectively. Drugs EcoSide Advansa and Ecocide C have showed the lowest activity to all investigated microorganisms. The largest number of resistant cultures to the tested disinfectants have been registered in the bacteria of the genus Citrobacter spp. and Pseudomonas aeruginosa, while simultaneously noted resistance to 4–6 drugs.

The article presents the results of processing incubation chicken eggs with a pectin- based preparation to reduce microbial contamination of the egg shell. It was found that the use of a 1% solution of pectin before laying and on the 18,5th day of incubation reduces the total contamination of the shell by 78,9-98,4% and the frequency of excretion of microflora by 10-100% in comparison with the control, we treat with formaldehyde vapor. This made it possible to increase the hatchability of eggs by 2,69%.

The hatchery is an important link in the production process of a poultry enterprise, and therefore there is a need to take eff ective measures to prevent the penetration and spread of infection. For this purpose hatching eggs are processed, veterinary and sanitary measures are carried out using disinfectants. The most common chemical disinfectants, but many of them have a short-term eff ect and have a negative infl uence on the embryos, and the task of any incubator is to get high-quality young birds. In most cases poultry farms use formalin, which when used repeatedly has a negative enfl uence not only on the embryos and their development, but also on the maintenance staff . In this regard, the creation of non-toxic, highly eff ective, eco-friendly products that do not pollute the environment, inhibit the growth of microorganisms that do not aff ect the embryo and maintenance personnel is an urgent task for veterinary science and practice. One of these drugs is a complex of coniferous balsamic fi r. The purpose of our researches was to study the infl uence of treatment of hatching eggs with the new drug on the fetal and postnatal development of quails. Egg processing has been performed before laying and during transfer in 15,5 days: in the experimental group with coniferous complex, in the control group with formalin. Biological control has been carried out in 9,5 and 15,5 days, taking into account the hatchability of eggs, the livability and live weight of quails. Blood has been collected at the age of 7 and 14 days for biochemical analysis, examining it for the content of total protein, albumins and globulins. The complex coniferous balsamic fi r did not have the negative infl uence on the fetal and postnatal development of the resulting young birds increased the hatchability of eggs, the livability and live weight of quails. Thus, the live weight of quails in the experimental group at the age of 7 days exceeded the control by 2,3 %, and at 14 days by 0,3 %. The livability of quails obtained from eggs treated with the studied drug the period of 1–14 days was 2,0 % higher compared to the control group.

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This article is devoted to the development of a new method for the prevention of avian bacterial diseases using a probiotic at various stages of the technological cycle at a poultry farm, including managing laying hens of the parent flock, incubating and broiler rearing. We used the-Organix‖ probiotic in the experiment, which was sprayed using a cold fog generator according to the developed schemes. The use of this method reduces the total microbial background in incubators and in facilities of keeping the broiler chickens and laying hens, reduces the growth of pathogenic and opportunistic microorganisms, creates a healthy microbial background, reduces the amount of ammonia in poultry houses and the effect of harmful microorganisms on the macroorganism. This positively affects the embryonic development and postnatal developing of birds, enhances the metabolism in their body. The hatchability rate is increased by 2.7%, the viability of laying hens and broilers is increased by 1.9% and 2.8%, the intensity of egg production and meat yieldby 3.6% and 4.2%, the profitability of hatching egg and broiler productionby 7.2% and 4.5%. The developed method contributes to the production of safe poultry products without antibacterial drugs use.