Summary. Students of dentistry faculties need a special methodological approach aimed at the acquisition of practical skills, but the study of fundamental disciplines is different from the dental-oriented ones. The aim of the study – to assess presumed deficits in the histology, cytology, and embryology knowledge of dentistry students at O. Bohomolets National Medical University, to identify the problems associated with it, and to address them. Materials and Methods. Testing of students of different courses of O. Bohomolets National Medical University using the standard licensed examination tests ‘‘Step 1 Dentistry’’. Results and Discussion. Students of the dentistry faculty have shown the level of students’ knowledge at 4th and 5th years – 33.5 %. The general result of the ‘‘Step 1 Dentistry’’ license exam in the same students is 66.6 % (2019) and 62.2 % (2018), respectively. The percentage of this result of the test higher when checked professional direct knowledge. We found that it was determined the prevalence of correct answers in the block on the topic "Oral Cavity" at the test on histology, cytology and embryology of  O. Bohomolets NMU Dentistry Faculty different courses students. Conclusions. In accordance with the obtained results and the analysis of the problems, it is recommended to make adjustments to the curricula and control measures with a focus on the competencies that will be applied in professional activities.