No abstract

The principle of chemical modification of known natural and synthetic biologically active substances and their precursors is, up to the present time, one of the bases in the strategy of designing new drugs [1], chemical agents for protecting and treating plants and animals [2], and also food additives [3]. As a continuation of the systematic investigation of the chemistry [4, 5] and biological activity [6, 7] of indenopyridine derivatives we have in the present work introduced the problem of studying the direction of the conversions of N-alkyl-9-phenyl-2,3-dihydro-1H-indeno[2,1-c]pyridines 1a,b on interacting them with sodium nitrite in acid medium, and also with benzohydroxymoyl chloride in the presence of base. The importance of the functionalization of these close precursors of the antiallergic agent thephorin [1] is evident, although it is impossible to consider the target chemical modification of the latter a very simple problem, if the extremely significant chemical lability of the precursors is taken into consideration [5]. First of all, on studying the reaction between sodium nitrite and indenopyridines 1a,b it was established that the main products are the 4-nitro derivatives 2a,b, isolated by column chromatography as garnet-red crystals in yields of 50 and 49% respectively. __________________________________________________________________________________________

The oxidation of title compound (I) by air, MnO2, and KMnO4 is studied. -(VOLKOV, S. V.; LEVOV, A. N.; VOLKOVA, O. E.; KOLYADINA, N. M.; POLYANSKII, K. B.; SOLDATENKOV, A. T.; Chem. Heterocycl. Compd. (N. Y.) 42 (2006) 5, 636-641; Russ. Peoples' Friendship Univ., Moscow 117198, Russia; Eng.) -H. Haber 05-145

Fused pyridine derivatives R 0450Synthesis and Molecular Structure of 4-Nitro-9-phenyl-1H-and 9-Hydroxy-3-oxo-9-phenyl-2,3-dihydro-9H-indeno[2,1-c]pyridines and 3,7-Diphenyl--3a,4,5,6-tetrahydroindeno[2,1-c]isoxazolo[5,4-d]pyridine. -The reactions of the indenopyridines (I) with both sodium nitrite and benzonitrile N-oxide are studied. Compound (IIa), whose structure is proved by X-ray analysis, is described as a promising substance for pharmacological tests. -(VOLKOV, S. V.; LEVOV, A. N.; SOLDATENKOV, A. T.; KOLYADINA, N. M.; VOLKOVA, O. E.; KHRUSTALEV, V. N.; Chem. Heterocycl. Compd. (N. Y.) 43 (2007) 9, 1181-1188; People's Friendship Univ., Moscow 117198, Russia; Eng.) -H. Haber