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Contact Nd.YAG laser conization (laser cone) was performed in 500 patients with preoperatively diagnosed cervical intraepithelial neoplasia (CIN) since September 1983. The patients treated were followed for 12 to 96 months (39.2 months on average). Average operation time was 11.4 minutes. A cure with laser cone (single treatment) was achieved in 98.6%, including cases with microinvasive and invasive carcinoma, post-operatively. There were only 7 (1.4%) true residual cases of 47 cases (9.4% of total cases) with incomplete excision. High spontaneous cure rates (85.1%) in cases with incomplete excision are considered to be a characteristic of laser cone treatment. The contact laser cone method also got good specimens for histologic examinations. They gave a large amount of information for our follow-up. The results indicate that contact Nd.YAG laser conization for CIN is an excellent conservative therapy from the point of cure rate, safety, indication, operation time and cone specimen, even compared with CO2 laser conization.

Abstract.The localization of cyclooxygenase and prostaglandin 12 synthase in human female reproductive organs was examined by immunohistochemistry. Cyclooxygenase was localized in the cytoplasm of various cell types. The extent of cyclooxygenase expression in endometrial epithelial cells varied with the menstrual cycle, showing a peak at the secretory phase. Cyclooxygenase was also detected in the secretory cells, but not in the ciliated cells, of the fallopian tubes. Prostaglandin I2 synthase was detected in the cytoplasm of myometrial cells throughout the menstrual cycle and during pregnancy. The results suggest that cyclooxygenase expression in endometrial epithelial cells may be regulated by ovarian hormones, and that the localization of cyclooxygenase in secretory cells--but not ciliated cells--in the fallopian tube may reflect the different functions of these two cell types.