One studied immunologic and genetic aspects of spontaneous abortion and the placenta insufficiency role in this pathology. It was determined, that increasing the production of cytokines by placenta's macrophages through something leads to increasing the reduced myometrium activity. Under cariotyping husbands and wives had spontaneous abortions on early terms it was found various genic and endocrine disturbtions. Modern topic diagnostics and algorithm of pregnancy observation with consideration of spontaneous abortion etiopathogenesis, treatment and placenta insufficiency prophylactics have permitted in most cases (more 93%) to give normal term of birth, to decrease perinatal losses.

The aim of the research was to investigate the pathomorphological changes in placentas of women with recurrent pregnancy losses under action of different injuring stimulus (infection, hormonal, biochemical reactions on membrans of syncytiotrophoblast and endothelium of placental vessels, actions of antiphospholipid antibodies). Identical changes was detected which connected with immune complexes (IC) formation. IC with different composition generate immunopathological processes in placental tissues. Present of antiphospholipid antibodies on placental membranes enhancing immunopathological processes, leading to dystrophic and necrotic lesions in surrounding tissues and to placental insufficiency. The outcome of this lesions is incompetent pregnancy. Therefore IC may be the marker of placental injury and insufficiency as well as a biologic indicator of failure in reproductive system. The treatment of threatened abortion is improve pregnancy outcomes and immunomorphological evidence.

Miscarriage is a serious problem of pregnancies resulting from overcoming infertility using assisted reproductive technologies (ART). The overall frequency of losses due to miscarriages of various periods and non-developing pregnancies reaches 30-35%. In order to optimize the outcomes of pregnancies resulting from ART, we have developed a special program that includes activities that are carried out at various stages, including at the stage of preparation for ART. In accordance with this program, all women in the period of preparation for the procedure undergo a full clinical and laboratory examination, including the consultation of a therapist, and, if indicated, other specialists (endocrinologist, ophthalmologist, etc.) in order to identify and correct concomitant diseases that can have an unfavorable influence on the course of pregnancy and childbirth.