A biogenic stimulant (Patent RU 2648466) was used as a study subject. Comparison objects are Ligfolum and Spleninum. Nonspecific resistance of experimental animals was estimated with the use of some leucocytal indices: the Krebs index (KI), leucocytal index of intoxication (LII), white blood cells dislocation index (WBCDI) -according to Jabluchanskij A.A., leukocytal index (LI). It was established that induced stress influenced directly by the number of leucocytes. Induced stress also had an impact on the blood leucogram of the animals undergoing the stress and taking part in the experiment. Leucocytal indices were figured out for animals' complex immunological status in dedication of the stress condition and immunomodulators application. Krebs index, which is the ratio between neutrophilic leucocyte and lymphocyte cells, characterizes indirectly an activity level of phagocytal reactions and non-specific immune system factors, as well as their involvement in general organism reactivity support. A ratio of the neutrophilic leucocyte level and the amount of lymphocyte cells, monocytes and eosinophils characterize Leucocytal index of intoxication (LII), characterize the activity level of phagocytosis and neutrophilic leucocyte proliferation. During the experiment, white blood cells dislocation index (WBCDI) characterizes the ratio between granular leucocyte and agranular leukocyte. The ratio between lymphocytes and neutrophils is described by leukocytal index (LI), which characterizes the ratio between humoral and cellulated elements of the experimental animals' immune system. Relations between the affecter and effector elements of the immunological process are characterized by lymphocytes and monocytes ratio index (LMRI), which describes the balance between lymphocytes and monocytes.