Неврологическое отделение ГБУЗ «Научно-исследовательский институт-Краевая клиническая больница № 1 имени профессора С.В. Очаповского» Министерства здравоохранения Краснодарского края Российская Федерация, 350086 Краснодар, ул. 1 Мая, д. 167 Кафедра нервных болезней и нейрохирургии с курсом нервных болезней и нейрохирургии ФПК и ППС ФГБОУ ВО «Кубанский государственный медицинский университет» Министерства здравоохранения Российской Федерации Российская Федерация, 350063 Краснодар, ул. Митрофана Седина, д. 4 * Контактная информация: Жадан Ольга Николаевна, врач высшей категории, заведующая отделением нейрореабилитации ГБУЗ «НИИ-Краевая клиническая больница №1 имени профессора С.В. Очаповского».

Christian–Weber disease refers to the group of panniculitis, which present an inflammation of the subcutaneous adipose tissue with the involvement of neutrophils, white blood cells and histiocytics, which leads to fibrosis in adipose tissue and sometimes to granulomatous changes. Clinically this pathology manifests from the formation of nodes in the subcutaneous adipose tissue, which appear suddenly, sporadically in some areas or multiple, sometimes forming large aggregations (plaques) or strands, shaped like a rosary. Consistency of nodes initially soft, then compacted, can form adhesions with the skin, the skin over them is not changed initially, followed by a color change from bright pink to brown-purple. Ends the process of atrophy of the affected area, sometimes with a depression in the center. Localization sites in the body are different; they are placed often on the buttocks, arms and legs. The duration of the process of the skin varies from a few days to a few months, after involution of old nodes may appear new ones, it are the cause of increasing the duration of the disease, having a relapsing course. It can be rather difficult to do differential diagnosis, which requires a great deal of experience of experts and a team approach to the study and treatment of this pathology. To confirm the diagnosis requires a biopsy of the skin. Prognosis depends on the nature of the disease and timely diagnosis.