Purpose of the article: to identify and compare career orientations and professional responsibility peculiarities in women with different sexual orientations to determine whether members of sexual minorities (SM) in Ukraine are less adapted to professional activity than members of the heterosexual majority. The study involved 162 Ukrainian women aged 16-46, including 36 lesbians, 76 bisexuals and 50 heterosexual women. The study had a cross-sectional design. It was used Career Orientations Inventory of E. Schein and standardized interview "Components of responsibility" of V. Ye. Kupchenko. It was found that bisexual women significantly less than women of other sexual orientations choose such career paths as General management, Pure challenge, Life Style and Entrepreneurial Creativity, which may be related to the general ambivalence of their life, which is set by their sexual orientation. Such career orientations may require self-confidence, a clarity of self-identity, which women with fluctuating sexual orientations may lack. A distinctive feature of lesbians was their greater understanding of the responsibility concept, which can be explained by the lack of an opportunity in their life to assign professional responsibility to a man, which corresponds to the traditional gender roles distribution. In general, it cannot be said that female SM representatives are significantly worse adapted to professional life than heterosexual women. The group of bisexual women can be considered as the most vulnerable.