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Introduction: Recently, radiofrequency ablation (RFA) has been increasingly used for the treatment of thyroid nodules. However, immediate morphological changes associated with bipolar devices are poorly shown. Aims: To present the results of analysis of gross and microscopic alterations in human thyroid tissue induced by RFA delivered through the application of the original patented device. Materials and methods: In total, there were 37 surgically removed thyroid glands in females aged 32–67 at presentation: 16 nodules were follicular adenoma (labelled as ‘parenchymal’ solid benign nodules) and adenomatous colloid goitre was represented by 21 cases. The thyroid gland was routinely processed and the nodules were sliced into two parts – one was a subject for histological routine processing according to the principles that universally apply in surgical pathology, the other one was used for the RFA procedure. Results: No significant difference in size reduction between parenchymal and colloid nodules was revealed (p>0.1, t-test) straight after the treatment. In addition, RFA equally effectively induced necrosis in follicular adenoma and adenomatous colloid goitre (p>0.1, analysis of variance test). As expected, tumour size correlated with size reduction (the smaller the size of the nodule, the greater percentage of the nodule volume that was ablated): r=-0.48 (p<0.0001). Conclusion: The results make it possible to move from ex vivo experiments to clinical practice.

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Accurately measuring blood flow in eye is an important challenge, as blood flow reflects the health of eye and is disrupted in many diseases. Existing techniques for measuring blood flow are limited due to the complex assumptions and calculations required. Digital image and video processing techniques started to be used for eye vessels analysis and evaluation during last decades. In this paper, we propose a method for determining the characteristics of blood flow in the vessels of eye conjunctiva, such as linear and volumetric blood speed, and topological characteristics of vascular net. The method first analyses image frame by frame sequentially and then builds integral optical flow for video sequence. Dynamic characteristics of eye vessels are introduced and calculated. These characteristics make it possible to determine changes in blood flow in eye vessels. We show the efficiency of our method in real eye vessels scenes.Povzetek: Razvit je nov sistem za določanje pretoka krvi v očeh.

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