The perimenopausal period is the age of the highest spiritual and intellectual development of a woman; therefore, neurovegetative and psycho-emotional disorders of this period acquire a pecial medical and social value and require an interdisciplinary approach. Objective: to identify the psychological characteristics of women with mild and moderate menopausal disorders in the perimenopausal period. Materials and methods. A total of 51 women were examined in the perimenopausal period: I main group - 20 patients with a low degree of CS, II main group - 16 women with menopausal disorders of moderate severity; the control group consisted of 15 healthy women. The severity of menopausal syndrome was determined using a modified menopausal Cooperman's index. All patients underwent psychodiagnostic examination using reactive and personal anxiety scales according to Ch.D. Spielberg and J.L. Hanina, G. Eisenko's test questionnaire, the Women's Sexual Function Index (FSFI) questionnaire, used the SF-36 (Medical Outcomes Study Short Form) general questionnaire to assess quality of life. Results. In women of the main groups, neurovegetative (14,5±2,6 and 26,6±4,2 points in the first and second groups of observation) and psycho-emotional disorders (4,9±1.3 and 11,2±1,6 points) prevailed. respectively). Hormone levels (FSH, E2, PRL) corresponded to perimenopausal values, but were significantly different from those of the control group. Identified individual-personal properties of women with the CS, in particular introversion and emotional instability. A comparative analysis on the Spielberg-Khanin scales showed that more than half (55,0 %) in the first main group and the majority (81,25 %) of women in the second main group versus 33,35 % in the control group (p˂0,05), a high level of personal anxiety was diagnosed; the average level of situational anxiety was highest among women in group II – 54,83±6,0 points versus 43,2±5,3 points in the first group and 36,3±4,8 points in patients without menopausal disorders (p˂ 0,05). In 24 (77,42 %) women of the main group, sexual dysfunction was detected, while its degree was greatest with moderately severe climacteric disorders. Menopausal disorders of varying severity, increased anxiety and neuroticism, sexual dysfunction affected the quality of life of patients. Conclusion. Formed psychopersonal characteristics of women with varying degrees of menopausal disorders in the perimenopausal period.

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This paper deals with study of the characteristics of clinical course of benign ovarian tumor formations in women of reproductive age, depending on the fertility and the choice of treatment strategy. Functional ovarian cysts in 60,45 % of cases were diagnosed in parous patients, in 39,55 % -in nulliparous women, in 5,22 % -in women with infertility. Corpus luteum cysts in 36,96 % of cases occured in nulliparous patients, whereas follicular cysts were more common for parous women (28,4 %) and infertile patients (28,57 %). The clinical picture of ovarian retention formations to 56,72 % of cases manifested by the pain syndrome in all patients, regardless of parity, whereas cycle disorders were more specific for parous patients (37,04 %). In 14,29 % of patients with infertility ovarian tumor formations were asymptomatic. In nulliparous patients inflammation of the uterine appendages was diagnosed significantly more often than in parous women. Increasing of the frequency of the myometrium pathology in the group of parous patients was significantly more often than in nulliparous women. Lack of individualization of the diagnostic algorithm, low commitment to hormonal, immunomodulatory therapy, use of standard antibiotic regimens led to ineffective treatment measures and to the formation of antibiotic resistance and the development of the process relapse.

Conducting a qualitative and comprehensive examination of patients with functional ovarian cysts is fundamentally necessary to understand the treatment strategy of this pathological state. The objective of the work was to study the features of immune disorders in patients of reproductive age with functional ovarian cysts.  Methods. 50 patients of reproductive age with functional ovarian cysts were examined. General clinical, gynecological, ultrasound examination of the pelvic organs, a study of the state of the immune system were carried out. Results. In 70% of patients chronic inflammatory processes of the pelvic organs were detected. The findings revealed varying degrees of immune system disorders in women with ovarian cysts with different parity. In nulliparous and women who gave birth violations of cell immunity of the I degree were revealed, in the group with infertility - II degree. In the group of patients who gave birth and with infertility, the III degree of disorders of humoral immunity was diagnosed, and in nulliparous women - II degree. Conclusion. Determining the degree of disorders of the immune system already at the prehospital stage will allow individualizing the choice and dosing regimen of immunomodulatory drugs as part of the complex therapy of functional ovarian cysts.

Стан клітинної та гуморальної ланок імунної системи у жінок репродуктивного віку з новоутвореннями яєчників О. С. Шаповал, Л. Л. ВоронцоваПорушення, що відбуваються в імунній системі у жінок із новоутвореннями яєчників, є одним із важливих факторів у патогенезі та розвитку захворювання. З метою вивчення особливостей імунних порушень у 105 жінок репродуктивного віку з новоутво-реннями яєчників визначили показники клітинного і гуморального імунітету. Встановили варіанти імунологічної реактивності при новоутвореннях яєчників у жінок із різними можливостями реалізації репродуктивної функції. Це свідчить, що виявлення на долікувальному етапі одного з варіантів порушення імунологічної реактивності є однією зі складових ефективності терапії, яка необхідна для вибору адекватної тактики лікувальної корекції гомеостазу організму.Ключові слова: новоутворення яєчників, клітинний імунітет, гуморальний імунітет. Conclusion. This indicates that the identifi cation of one of the variants of immunological reactivity disorder in the precurative stage is one of the components of the effective prescribed therapy necessary to select the appropriate tactics of medical correction of homeostasis.