No abstract

New thiazole and 1,2,4-triazole derivatives of 9,10-anthraquinone were obtained by the reaction of N-benzoyl-N'-(9,10dioxo-9,10-dihydroanthracene-1-yl)-thioureas with bromoacetone in the presence of triethylamine and hydrazine hydrate in chloroform, respectively. The PASS computer program was used to predict the biological activity spectra and to determine the most promising biological activities for experimental testing. Thus, it has been shown that the synthesized compounds are a promising class for the creation of substances with a wide range of biological activity.

The optimisation of reaction conditions for obtaining thiosulfonate derivatives was performed. S,N-binucleophiles (sodium salts of 4-amino-and 4-acetylaminobenzenethiosulfonic acids) were used. The parameters of the reaction for the synthesis of derivatives by a thiosulfonate fragment were determined. Thiosulfonate derivatives based on a number of quinones and quinoxalines were synthesized.

Objective.Verification of clinic–anatomical characteristics of trauma as a consequence of traffic accident in the megapolis environment. Materials and methods. Retrospective analysis of the data obtained was conducted in 1159 injured persons, who were traumatized as a consequence of a traffic accident in megapolis. Results.There was established, that as a result of traffic accident in the megapolis environment, the injured persons most frequently obtained trauma of the head – 68.31%, of thoracic cage – 57.07%, and of the extremities – 53.99%. The majority of the injured persons survived have had the trauma of the head (67.13%), of the thoracic cage (55.74%) and extremities (53.63%), while mostly rare – pelvic trauma (15.70%). Among the injured persons, who died, the head injuries was noted in 94.0%, thoracic trauma – in 86.0%, and abdominal injuries – in 76.0%. Conclusion.Trauma as a consequence of traffic accident in the megapolis environment constitutes a multicomponent injury (2.4 damages in every injured person). The result of the traumatic process course depends on the injury composition (in the injured persons survived, the combination coefficient was 2.3, while in the dead – 3.8) and on damage of a certain anatomic–functional local site.The head, thoracic and pelvic sites have constituted the most dangerous localizations.

No abstract