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The ¹⁴CO₂ production from glucose U-¹⁴C was studiedin hypothalamus and cerebral cortex of the following groups of rats: normal males, normale females during the different phases of the sexual cycle, androgenized females, and castrated females. ¹⁴CO₂ production was significantly higher in the hypothalamus during estrus than in diestrus. Males and androgenized females showed values similar to those found in diestrous rats. The oxidative activity in the hypothalamus of 7-day castrated rats is similar to that observed in diestrous rats and lower than the activity found during estrous and in 30-days castrated rats. Between the different groups studied, no modifications were found in the respiratory activity of the cerebral cortex.

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