Relevance. Clinical and radiological assessment mainly forms the diagnosis of periodontal diseases. The diagnosis now requires speed, sensitivity and specificity since determining the patient's disease stage is fundamental to effective treatment. Crevicular fluid biomarkers can help monitor the current state of the disease, the effectiveness of treatment, and possibly predict the pathological process progression. The combination of various biomarkers will allow maximum objectivity in periodontal tissue condition assessment.Materials and methods. The study examined 72 patients with inflammatory periodontal diseases and 25 periodontally healthy subjects. We performed a conventional clinical-instrumental examination and studied pro- and anti-inflammatory interleukins (IL-1β, IL-6, IL-17, TNF-α, VEGF, IL-8, MCP-1, IL-1RA) in the crevicular fluid. The obtained materials were processed using ROC analysis.Results. Inflammatory periodontal diseases demonstrate an increase in pro-inflammatory cytokines / chemokines (IL-1β, TNF-α, IL-6, IL-17, IL-8, MCP-1) and vascular endothelial growth factor (VEGF) in the crevicular fluid, a decrease in the anti-inflammatory cytokine, IL-1RA. The levels of pro- and anti-inflammatory cytokines, cytokines/ chemokines, VEGF are associated with the periodontal destruction severity caused by inflammation. The accumulation of VEGF, IL-6, and IL-1β in the crevicular fluid predicts the clinical course of gingivitis, VEGF, TNF-α, IL-6, IL-1β – mild and moderate periodontitis.Conclusion. The present study allows us to confirm the diagnostic value of methods for obtaining and quantifying a group of immunoregulatory cytokines in the crevicular fluid as predictors and parameters of the disease progression and the development of osteodestructive changes in the periodontium.

The frequency and clinical course of chronic generalized periodontitis against the background of liver cirrhosis of various etiologies were studied. 70 patients with chronic generalized periodontitis of varying degrees in combination with liver cirrhosis were examined (23 patients (32.9%) had liver cirrhosis class A, 25 (35.7%) — class B, 22 (31.4%) — class C. Comparison group — 17 patients with periodontitis without somatic pathology. Control group — 20 practically healthy volunteers. A signifi cantly reduced level of oral hygiene was revealed in patients with liver cirrhosis of classes B and C. Periodontal pathogenic microorganisms were signifi cantly more common in the contents of periodontal pockets with cirrhosis. With an increase in the class of CP, the frequency of bacterial expansion increased. The severity of periodontal damage in patients with liver cirrhosis is associated with a loss of bone mineral density by the type of osteopenia (47.2%) or osteoporosis (31.4%), increasing according to the class of liver cirrhosis and the severity of periodontal disease The degree of resorption of the alveolar process is associated with a systemic decrease in bone mineral density. The eff ects of generalized osteopenic syndrome and resorption of the alveolar processes are characteristic of patients with alcoholic liver damage and liver cirrhosis with cholestasis syndrome.