Цель работы-изучить состояние сердечно-сосудистой системы у детей школьного возраста в зависимости от уровня контроля бронхиальной астмы.

Objective. To study specific features of potassium metabolism and myocardial damage markers in the children with bronchial asthma, depending on the level of BA control. Materials and methods. Comprehensive examination was carried out in 189 children with persistent BA aged 6-17 years: group 1 consisted of 124 with uncontrolled course of the disease, group 2-30 patients with partially controlled BA and 35 patients with controlled BA. The comparison group consisted of 30 patients with controlled asthma without changes from the cardiovascular system. The unified flame photometry method with fluid analyzer FFA-1 was used to determine the erythrocyte potassium level. Total creatine phosphokinase level was estimated by UV-test. Creatine phosphokinase-MB level was determined by M-subunit immunoinhibition. Total lactic dehydrogenase-1 level was calculated by modified colorimetric method using an assay kit for colorimetric determination of total LDH. Serum LDH1 level was estimated by UV-method with the kit for determination of isoenzyme LDH1 activity. Results. In the children with UC BA serum K + and erythrocyte K + level was significantly lower compared to the children with PC BA, C BA, C BA with no changes in CVS and the control group. Total CPK and CPK-MB isoenzyme level in the children with UC BA, was significantly higher compared to those with PC BA, C BA, C BA without CVS changes and the control group. In the children with PC BA, total serum CPK level was also significantly higher compared to C BA (P = 0.007), C BA without CVS (P = 0.0002) changes and the control group (P = 0.001). Conclusion. Thus, the study demonstrated significant decrease of potassium level in blood serum and erythrocytes, twofold increase of total creatine phosphokinase and lactic dehydrogenase-1 isoenzyme levels, threefold increase in creatine phosphokinase-MB isoenzyme level, and one and a half time increase of total lactic dehydrogenase in the children with uncontrolled course of bronchial asthma.

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Objective-to study the indices of general and specific quality of life in schoolchildren, depending on the level of bronchial asthma control. Materials and methods. Quality of life parameters of 189 in-patients with BA, aged 6-17 years and 95 controls were studied. Parallel questioning with subsequent analysis of quality of life indices in 189 parents of BA children and 95 parents of the control group children was performed. General QL was evaluated using РedsQL (Pediatric Quality of Life Inventory 4.0). Specific quality of life was evaluated using specific quality of life questionnaire for the children ill with bronchial asthma-PAQLQ (Pediatric Asthma Quality of Life Questionnaire). Statistical analysis of the data obtained was done by variance statistical methods using the standard program package of multivariate statistical analysis Statistica 6.0 Results. The study found the index of physical functioning to be 43.6 [31.3-62.5] points in the children with UC BA, 53.1 [37.5-68.2] points in those with PC BA, being significantly lower as compared to the control group children-79.6 [56.0-100.0] points (P < 0.001). Рhysical functioning index in the children with UC BA was 1.7 times lower as compared to those with C BA. Comparison of the indices in those with PC BA-53,1 [37.5-68.2] points and C BA-74.1 [50.0-76.0] points, showed that physical activity in the children with PC BA was significantly lower as compared to those with C BA (P < 0.001). The analysis showed no significant difference between the answers of the children with asthma and their parents. No significant difference between the answers of healthy children's parents and the children themselves was revealed as well (P > 0.05). The cumulative index of QL was dependent on the level of BA control. It was 2.5 [1.4-3.6] points in the children with UC BA, being significantly lower as compared to those with PC BA-3.9 [2.8-4.9] points, and C BA-6.2 [5.6-6.8] points (P < 0.001); and in the children with PC BA this index was significantly lower as compared to those with C BA (P < 0.01). Conclusions. Along with traditional methods of assessment of respiratory function and laboratory indices of inflammatory process activity in bronchial asthma, study of physical and mental health, social activity, general wellbeing and many other parameters of quality of life, as well as the influence of treatment on these parameters should be carried out.