результати лікування 356 пацієнтів з гострим асептичним некротичним панкреатитом віком від 21 до 82 років. Встановлено, що найчастішим ускладненням гострого асептичного некротичного панкреатиту є парапанкреатичний інфільтрат, який виявлений практично у всіх хворих. Доведено, що диференційований підхід до показань, термінів виконання, вибору способу і об'єму хірургічного втручання при гострому асептичному некротичному панкреатиті дозволив знизити післяопераційну летальність до 3,9%. При гострих асептичних парапанкреатичних рідинних скупченнях летальність становила 2,9%: при ГАРС-СС-1,3%, при ГАРС-ЗК-8,2%. У цілому при гострих асептичних парапанкреатичних рідинних скупченнях у 91,7% пацієнтів вдалося уникнути розвитку гнійних ускладнень. Ключові слова: гострий асептичний некротичний панкреатит, хірургічна тактика.
Over the last decade, the issue of treatment of acute necrotizing pancreatitis has been requiring special attention because of the growth of this pathology worldwide and high mortality from it, especially with extended infected types of the disease.The aim of the research was to improve results of treatment of patients with nonbiliary necrotizing pancreatitis by optimizing of the surgical tactics, which depend on the extent of necrosis in the pancreas and peripancreatic fat. Materials and methods.The study analyzed results of treatment of 220 patients with acute nonbiliary necrotizing pancreatitis, who were hospitalized in the clinic from 2014 to 2016. The age of the patients ranged from 18 to 80 years, including patients under the age of 50, who accounted for 54 %. Comparison of qualitative features was carried out through analysis of conjugacy tables, using the χ² Pearson criterion (Pearson Chi-square). For four-field tables (for 1 degree of freedom), the Yates's correction was used. When comparing the groups, the level of statistical significance (P) was calculated. At P < 0.05, the differences were considered statistically significant. Results.The research argues that mortality depends not only on the extent of pancreatic necrosis, but also on the choice of method of surgical intervention. Use of puncture-draining operations under ultrasound control and lumbotomy made it possible to reduce postoperative mortality from lesser sac abscess from 6.5 % to 3.9 %, from retroperitoneal phlegmon -from 31.6 % to 15.8 %, and from their combination -from 60.0 % to 33.3 %. In cases of diffuse purulent peritonitis, mortality from laparostomy combined with the programmed sanitation of the abdominal cavity was 40 %; it included cases when carbapenem antibiotics (imipenem/cilastatin, and meropenem) were used in the complex treatment, accounting for 33.3 %, and cases of implementing laparostomy, sanitation, and drainage of the abdominal cavity, making 50 %. Conclusions.The more extensive use of puncture-draining operations under ultrasound control and lumbotomy, as well as laparostomy in combination with the programmed sanitation of the abdominal cavity, allowed to reduce mortality from 26.1 % to 12.1 %.Порівняльне оцінювання різних способів хірургічного лікування небіліарного некротичного панкреатиту О. В. Розенко, Д. М. Синєпупов, А. М. Сорокін Мета роботи -поліпшити результати лікування хворих на небіліарний некротичний панкреатит шляхом оптимізації хірургічної тактики залежно від поширеності некрозу в підшлунковій залозі та парапанкреальній клітковині.Матеріали та методи. Проаналізували результати лікування 220 пацієнтів із гострим небіліарним некротичним пан-креатитом, які перебували на стаціонарному лікуванні у клініці з 2014 до 2016 року. Вік пацієнтів -від 18 до 80 років, 54 % хворих були віком до 50 років. Якісні ознаки порівнювали за допомогою аналізу таблиць спряженості за допо-могою критерію χ² Пірсона (Pearson Chi-square). Для чотирипільних таблиць (для 1 ступеня свободи) використовували поправку Йейтса (Yates's ...
Background. In connection with a steady increase of patients with destructive forms of acute pancreatitis, the proportion of which takes from 10-15 to 20-30%, despite of the wide range of treatments for non-biliary necrotizing pancreatitis, the rate of mortality reaches 80-90% in case of infected forms and needs further improvement of therapies. Objective. The purpose of this study is to improve the results of treatment of patients with nonbiliary necrotizing pancreatitis, by optimizing surgical tactics. Methods. The study examined the cases of 120 patients, whose age ranged from 22 to 83 years, including patients under the age of 50 years old who accounted for 60.0%. There were 80 males (66.7%) and 40 females (33.3%). Disease duration up to 24 hours was found in 36 (30.0%) patients, from 25 to 72 hours - in 25 (20.8%) individuals, more than 72 hours - in 49 (49.2%) patients. Results. The research claims in non-necrotizing pancreatitis, left-sided retroperitoneal phlegmon often develops in 64.2% (mortality rate 26.0%) of patients, right-sided in 24.2% (mortality rate 6.8%) of patients, and bilateral - in 11, 6% (mortality rate 64.2%) individuals. Moreover, the highest mortality was observed with a combination of retroperitoneal phlegmon cellulose and abscess of the pancreas and/or omental bursa - 39.1%. Conclusions. The use of various surgical interventions depending on the involvement in the pathological process of various sections of the abdominal cavity/ retroperitoneal space, which made it possible to reduce mortality and hospitalization time of patients in the hospital by 1.5-2 times is proposed.
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