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We studied the capacity of outer membrane pore-forming recombinant protein from Yersinia pseudotuberculosis to initiate the development of immune response in CBA mice. Immunization with the recombinant protein induces the production of IgG antibodies with and without adjuvants. High-avidity immune serum was obtained as a result of immunization. Bactericidal activity of peritoneal macrophages from mice immunized with recombinant protein was significantly higher than that of intact mouse macrophages. The use of recombinant porin instead of native porin as the antigen in enzyme immunoassay system for the diagnosis of acute and secondary focal pseudotuberculosis does not reduce the efficiency of detection of specific antibodies in the sera of patients.