Background and objectives: COVID-19 pandemic had quite a significant impact on a number of obstetric outcomes. This is often directly attributed to complications of COVID-19. This article is a systematically review literature on the epidemiology, clinical features, maternal and perinatal outcomes of COVID-19 in pregnancy.Materials and methods. A PRISMA methodology search was conducted on the databases of PubMed, Scopus, Medline, Google Scholar, Web of Science and Central BMJ using MeSH keywords or combinations of the words “COVID-19”, “SARS-CoV-2”, “pregnancy”, “epidemiology”, “comorbid disease”, “pregnancy and childbirth outcome”, “preeclampsia”, “fetus”. Only articles published between December 1, 2019 to February 28, 2022 were considered. After preliminary analysis of more than 600 publications, 21 articles were short-listed for final processing. The studies were selected using a Newcastle-Ottawa scale style questionnaire. The clinical features, risk factors, co-morbid conditions, maternal and neonatal outcomes were presented in two separate tables respectively. Results. COVID-19 incidence in pregnancy ranged from 4.9% to 10.0%. Such women were 5.4 times more likely to be hospitalized and 1.5 times more to need ICU care. Dyspnoea and hyperthermia were associated with a high risk of severe maternal (OR 2.56; 95% CI 1.92–3.40) and neonatal complications (OR 4.97; 95% CI 2.11–11.69). One in ten of neonates had a small weight for gestational age (9.27 ± 3.18%) and one in three required intensive care unit observation.Conclusions. Despite the increasingly emerging evidence on the associations between pregnancy and COVID-19 infection, the data is sometimes contradictory necessitating further studies.

The aim of the study – to learn the expression of VEGF and HIF-1α in physiological, hyperplastic, atypical endometrium at different ages of women. Materials and Methods. Evaluation of VEGF expression and HIF-1α performed in endometrial tissue samples in 458 women of late reproductive, perimenopausal and postmenopausal age. Expression of VEGF and HIF-1α was performed at the mRNA level by polymerase chain reaction of cDNA obtained by reverse transcription. The results were processed by the method of variation statistics with the assessment of reliability according to the Student's criterion using standard computer systems. Results and Discussion. Analyzing the data of the presented work, higher VEGF expression rates were found in atypical hyperplasia in all age categories, but probably higher rates were found in the postmenopausal period, in atypical endometrial hyperplasia, which indicates the need for vigilance in detecting this process in the appropriate age category. Studies have shown that HIF-1α can potentiate the activation of vasomotor genes that are required for the vascular response to hypoxia. These studies demonstrate the informativeness of the method of determining HIF-1α in the examination of patients with endometrial hyperplastic processes (EHP). The introduction of this method in practical medicine will not only understand the details of the changes occurring in the body (pathological, physiological), but also develop strategic maneuvers for possible therapeutic or surgical treatments. Conclusions. Expression of VEGF and HIF-1α levels in endometrial tissue cells as a marker can be a promising method for diagnosing the risk of proliferative conditions and their prognosis, especially in combination with other markers that characterize immunohistochemical and molecular genetic cellular parameters. Hypoxia and its relationship with indicators of angiogenesis may have some promising significance. Because the development of pathological conditions develops at a certain stage of hypoxic conditions. Under certain conditions, as a result of disruption of tissue processes, possibly metabolic, changes in angiogenesis are reduced with increasing hypoxia, which may in the long run provoke atypical disorders.

Представлен клинический случай с описанием особенностей тактики ведения и родоразрешения пациентки с аномалиями развития мочеполовой системы у женщины 36 лет с полным удвоением матки и неполным удвоением единственной правой почки. Анамнез также отягощен субклиническим гипотиреозом, хроническим пиелонефритом единственной почки. В возрасте 21 года удалены оба яичника по причине воспалительных опухолей (пиоварум, пиосальпинкс). В 28 лет первая беременность с помощью ВРТ, родоразрешение кесаревым сечением в 38 недель. Данная многоплодная беременность также с помощью ВРТ, с расположением плодов в 2-х матках. Родоразрешена абдоминальным путем в сроке 33-34 недель нижнесрединным доступом с поэтапным корпоральным разрезом левой и правой матки. Выводы. Многоплодную беременность в настоящее время можно отнести к осложнениям вспомогательных репродуктивных технологий. Необходимо внедрение более широких междисциплинарных консилиумных биоэтических обсуждений при принятии пациенткой и ее семьей информированного решения о многоплодной беременности с учетом оценки общесоматического состояния женщины и адаптационно-компенсаторно-возможностей ее организма в условиях гестационного процесса.

No abstract

No abstract