Crambe cordifolia Steven is a perennial herb and contains many biologically active substances, including amino acids, quercetin and glycosides of kaempferol. In continuation of the investigation of these plant compounds, it is advisable to study the qualitative composition and quantitative contents of carboxylic acids. Using a HPLC method the quantitative content of the following organic acids was identified and determined: pyruvic (40.66 mg/g), isocitric (12.88 mg/g), citric (8.71 mg/g), succinic (38.03 mg/g) and malic (0.75 mg/g). Among fatty acids the saturated and unsaturated acids were determined by the GC/MS method. The content of polyunsaturated fatty acids of the total fatty acids was 56.97%, saturated – 38.53% and monounsaturated – 4.50%. Linolenic and palmitic acids dominated among the determined 7 fatty acids, their content was 9.68 mg/g (47.87%) and 4.88 mg/g (24.14%). The results of the study show that Crambe cordifolia Steven leaves is a source of carboxylic acids.

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Objective: The aim of our study was to establish the content of some primary metabolites, such as amino acids in Crambe cordifolia and Crambe koktebelica. The lack of experimental data induced us to determine these compounds. Methods: Crambe cordifolia and Crambe koktebelica leaves were selected as the objects of the study. The amino acids in the raw materials were determined by the HPLC method. Results: The results of the research revealed that the leaves of Crambe cordifolia and Crambe koktebelica contain fifteen and sixteen free amino acids respectively. Among the free amino acids L-histidine was presented in Crambe cordifolia leaves in the greatest amount, its content was 12.19 µg/mg. The content of free L-arginine, L-valine, L-phenylalanine, L-isoleucine was the greatest in Crambe koktebelica leaves, it was 2.23 µg/mg, 2.04 µg/mg, 1.74 µg/mg, 1.50 µg/mg respectively. The content of bound L-glutamic acid, Glycine, L-arginine, L-leucine was the highest in Crambe cordifolia and Crambe koktebelica leaves. Conclusion: The results of the study showed that Crambe cordifolia and Crambe koktebelica can be considered as a source of highly digestible amino acids that can be used to treat some diseases.

державний медичний університет імені І. Я. Горбачевського МОЗ України», 2 Національний ботанічний сад імені М. М. Гришка НАН України, м. Київ Мета роботи-встановлення якісного складу та визначення кількісного вмісту жирних кислот катрану серцелистого й катрану коктебельського листків. Матеріали та методи. Об'єкти для дослідження − катрану серцелистого листки та катрану коктебельського листки. Сировина, що надана відділом культурної флори Національного ботанічного саду імені М. М. Гришка НАН України, заготовлена влітку 2018 р. Якісний склад і кількісний вміст жирних кислот визначали методом газової хроматографії з мас-спектрометрією на хрoматoграфі Agilent 6890N із хрoматo-мас-спектрoметричним детектoрoм 5973 inert (Agilent Technologies, США).

The aim: to conduct epidemiological studies of the morbidity and mortality of the population from lymphogranulomatosis in the regions of the country in dynamics over the years and to identify regions of the country that require special attention in the process of early detection of this pathology and effective pharmaceutical provision of patients. Materials and methods. The object of the research was the official data of the National Cancer Registry from 2012-2019. The research used both general theoretical (historical, analytical and comparative, systemic, graphic, logical, hypothetical-deductive) and applied (mathematical-statistical, epidemiological) methods of research. Results. It has been established that the average morbidity and mortality rates of the population from lymphogranulomatosis in Ukraine exceed similar world data (morbidity/mortality -2.3/0.4 for men and 1.9/0.3 for women per 100 thousand population). Thus, the calculated morbidity rates were 2.5, and the mortality rate was 0.7 per 100 thousand population. It has been proved that morbidity and mortality rates by region varied in a significant range of values, namely, morbidityfrom 1.8 (Transcarpathian region) to 3.0 (Kyiv), and mortalityfrom 0.4 (Cherkasy region) to 0.9 (Ivano-Frankivsk, Kyiv, Chernivtsi regions) per 100 thousand population. According to the results of the grouping, most regions of the country (14 regions and Kyiv city) were assigned to the group of extremely unfavourable (group D) development of the epidemiological situation in terms of lymphogranulomatosis. Ivano-Frankivsk region was attributed to the group of unfavourable (group C) development of this process. Four (Transcarpathian, Vinnytsia, Zhytomyr and Kherson) regions were included in the group of favourable (group A) development of the epidemiological situation. The group of relatively favourable (group B)three areas. These are the Volyn, Chernigov and Cherkasy regions. Conclusions. The presence of an extremely unfavourable (14 regions and Kyiv city) and unfavourable (Ivano-Frankivsk region) onco-epidemiological situation necessitates the development and implementation of regional programs for the early detection of lymphogranulomatosis and the provision of patients with affordable and effective anticancer drugs in accordance with the existing resource provision at the level of regions and local communities