Breast cancer is the most commonly diagnosed cancer of women and the second leading cause of cancer deaths among women. Experiments in animal models of breast cancer have shown that matrix metalloproteinase (MMP) inhibitors can significantly reduce the growth rate of both primary and secondary tumors and can block the process of metastasis.(l) MMPs are

A new drug delivery system (DDS), ciprofloxacine/tricalcium phosphate delivery capsule (CTDC) was developed by loading a broad-spectrum antibiotic ciprofloxacine into the central cylindrical cavity of tricalcium phosphate capsule. The new system showed good biocompatibility and could degrade gradually in our preliminary studies. In vitro study showed that CTDC could maintain high-level and long-term release of ciprofloxacine and that ultrasonic irradiation within the range of physical therapy could increase the drug release amount from CTDC ( P < 0.02), and might become a new technique to achieve the control of drug release from DDS.