This study was aimed at determining the serum levels of Cystatin C in fibroid patients. A total of 140 women were recruited for the study, 70 served as control while 70 were fibroid patients (test). Nephelometric Immunoassay Method in Mispa autoanlyser was used for the assay. The data were analyzed with statistical package for social science (SPSS) version 20. The results showed significant difference (P<0.05) when Cystatin C in fibroid subjects (2.6 ± 1.11 mg/dl) were compared to control (1.0 ± 0.34 mg/dl) and there was significant difference (P<0.05) when Cystatin C levels were compared among the different age groups. It was concluded that Cystatin C was elevated in fibroid women.