Aim: The present study aimed to evaluate the effects of co-administering paracetamol and Goko cleanserâon the liver. Method: Twenty rats divided into four different groups were used for this Study. Group one (control group) received distilled water only; Group two received paracetamol only (100mg/kg), Group three received Goko cleanserâonly (2 mL/kg) and Group four received paracetamol and Goko cleanserâconcomitantly for 3 days. Blood and liver samples were analyzed for biochemical and histopathological parameters respectively. Results: Data obtained revealed a significant decrease (p<0.05) in the levels of the liver enzymes (ALT, AST, and GGT) in the Goko cleanserâ-only group compared to control. A significant decrease in AST was also observed in paracetamol + Goko cleanserâgroup. No significant change in ALT, ALP and GGT levels in the paracetamol + Goko cleanserâgroups was observed. Results of histology examination showed normal liver tissues with normal hepatocytes, sinusoids and central vein for both treated and control groups. Conclusion: The significant reductions in the liver enzymes by observed in the Goko cleanserâ-only group indicated potential hepato-protective effects which could be due to the presence of phenolic compounds which acted as antioxidants. The short-term co-administration of paracetamol and Goko cleanserâproduced no liver toxicity. However, this is subject to further studies using pharmacokinetic analysis and also, a long-term study is strongly advocated.                    Peer Review History: Received: 7 July 2021; Revised: 8 August; Accepted: 7 September, Available online: 15 September 2021 Academic Editor:  Essam Mohamed Eissa, Beni-Suef University, Egypt, dressamceutics@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id Dr. Dennis Amaechi, MrsFoluBabade Mini Estate , Flat 5 by Old Soldiers Quarter, Sabongari/Bwari, Abuja- Federal Capital Territory, Nigeria. amaechitoexcel@yahoo.com  Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my Taha A.I. El Bassossy, Medicinal and Aromatic Plants Department, Desert Research Center, Cairo, Egypt, tahachemist2008@gmail.com  Similar Articles: COMPARISION OF ANTIDYSLIPIEMIC POTENTIAL OF 80 MILLIGRAMS OF FENOFIBRATED WITH 8 GRAMS OF NIGELLA SATIVA SEEDS DAILY