Highlights d PDI-1, a protein disulfide isomerase, regulates neuron migration d PDI-1 functions in EGL-20/Wnt-producing cells to control neuron migration d Protein disulfide isomerases are evolutionarily conserved regulators of Wnt secretion

No abstract

No abstract

Highlights d PDI-1, a protein disulfide isomerase, regulates neuron migration d PDI-1 functions in EGL-20/Wnt-producing cells to control neuron migration d Protein disulfide isomerases are evolutionarily conserved regulators of Wnt secretion

Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming growth factor-beta (TGF-β) type I receptor SMA-6 (small-6) acts independently of its cognate TGF-β type II receptor DAF-4 (dauer formation-defective-4) to control neuronal guidance. SMA-6 directs neuronal development from the epidermis through interactions with three, orphan, TGF-β ligands. Intracellular signaling downstream of SMA-6 limits expression of NLR-1, an essential Neurexin-like cell adhesion receptor, to enable neuronal guidance. Together, our data identify an atypical TGF-β-mediated regulatory mechanism to ensure correct development of the nervous system.