Background: The primary causes of maternal mortality in Indonesia are hemorrhage (32%), preeclampsia/ eclampsia (25%), infection (5%), prolonged labor (5%), abortus (1%), and other causal factors not related to pregnancy and birth delivery (32%). This study aimed to investigate risk factors of post partum hemorrhage in Bondowoso, East Java. Subjects and Method: This was an analytic observational study with case control design. This study was conducted in Bondowoso, East Java, from May, 15 to June, 15, 2016. A total of 90 study subjects was selected by fixed disease sampling, consisting of 30 women with post-partum bleeding and 60 control women without post-partum bleeding. The dependent variable was post-partum hemorrhage. The independent variables were age, parity, hemoglobin, obstetric history, antenatal care (ANC), and type of birth attendant. The data were collected by questionnaire and medical record. The data were analyzed by mix-effect model. Results: Anemia (Hb <11 g%) (b=2.22; 95%CI=1.05 to 3.39; p=0.001) and obstetric history of bleeding (b=1.31; 95%CI= 0.15 to 2.47; p=0.027) increased the risk logodd of postpartum hemorrhage, and it was statistically significant. ANC ≥4 times (b=-1.46; 95%CI=-2.95 to 0.02; p= 0.052) decreased the risk logodd of postpartum hemorrhage, and it was marginally significant. Age <20 year or ≥ 35 year (b= 0.12; 95%CI= -1.01 to 1.26; p= 0.827) and parity = 1 or ≥4 (b= 0.18; 95%CI= -0.95 to 1.32; p=0.754) increased the risk logodd of postpartum hemorrhage, but it was not statistically significant. Multilevel analysis was not needed in this model because ICC <1%. Conclusion: Anemia and history of postpartum bleeding are important risk factors of postpartum hemorrhage. Use of ANC ≥4 times decreases the risk of postpartum bleeding.