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Introduction. Preserving employees’ health is one of the main components of corporate health and an essential factor of the social responsibility of business at the present stage of society’s development. The creation of “healthy” workplaces with the optimization of working conditions, preventive programs aimed at preventing occupational and general somatic diseases should become the main link in strengthening the health of the able-bodied population. The purpose of the study is to provide a scientific justification and develop a modular program for preserving the health of workers of mining enterprises with various methods of ore extraction (underground and open). Material and methods. The risk assessment of health disorders was carried out in stages: the state of working conditions, socio-demographic status were studied, behavioural risk factors were determined using questionnaires, fat metabolism was studied. Results. The main risk factors for health disorders of employees of mining enterprises were identified: working conditions that do not meet sanitary standards (noise and vibration class 3.1-3.3, physical overload class 3.1-3.2, high work intensity), behavioural factors including smoking, overweight and low physical activity, early violation of lipid metabolism. Discussion. Modular corporate programs have been developed to implement the principles of a healthy lifestyle (optimizing nutrition, increasing physical activity, stopping smoking, avoiding excessive alcohol consumption). The leading indicators of the effectiveness of the implementation of preventive measures are proposed. Conclusion. The development and application of effective health-saving corporate programs are the choices of a socially responsible business aimed at solving the following tasks: preserving the health of employees, increasing their motivation to comply with the principles of a healthy lifestyle, forming a responsible corporate culture and, as a result, increasing labour productivity. Creating and maintaining a healthy working environment leading to improved socio-economic development is one of the most effective investments in human capital.

Ntroduction. The article is devoted to the study of the features of the metabolic pathology of the liver under the influence of harmful industrial factors. The relevance of the study of nonalcoholic fatty liver disease of workers in contact with industrial aerosols is due to the high prevalence of the disease among the working-age population, the polyethological nature of the pathology, including the pathogenetic relationship with external household and occupational toxic effects. Materials and methods. The were examined two hundred four industrial production workers, divided into four groups according to the composition of the affected aerosol: copper-nickel ore dust, welding aerosol, quartz-containing dust, carbon-based dust. The survey was conducted using the AUDIT questionnaire, examination of patients, anthropometry, ultrasound examination of the abdominal organs, biochemical blood analysis, determination of viral hepatitis B and C markers, and serum immunoglobulins. Results. The frequency of detection of ultrasonic signs of liver damage in the examined patients who came into contact with copper-nickel aerosol dust significantly exceeds the same indicator of the studied patients who came into contact with quartz-containing dust (p<0.05) and also exceeds the frequency of detection in the group working under the influence of carbon-based and welding aerosol (p>0.05). Most often, an increase in the activity of liver enzymes was noted among those working in contact with copper-nickel ore dust. Significant differences were found between groups 1 and 3; 1 and 4 (p<0.05). There were no significant differences between the groups in the frequency of lipid and carbohydrate metabolism disorders and biliary tract pathology. Discussion. The results of the study may be related to the toxic effects of the copper-nickel aerosol but may also be associated with the climatogeographic features of the workers ‘ habitat. Conclusion. The prevalence of liver diseases in the group that came into contact with copper-nickel dust was established. The revealed changes do not depend on lipid and carbohydrate metabolism features, pathology of the biliary tract. For a detailed study of liver damage in industrial workers, it is necessary to conduct an in-depth study.

Introduction. The development of ferruginous quartzites of the Kursk magnetic anomaly basin is accompanied by the release of dust, which affects miners. Identification of markers of preclinical pathology of the cardiorespiratory system (CRS) is relevant. Objective is to identify markers of endothelial dysfunction (ED) (endothelin-1 (ET-1), brain natriuretic peptide (BNP), changes in the elastic properties of blood vessels) at the preclinical stage of the development of pathology of the cardiovascular system and pathology of the respiratory organs in workers of dust occupations with different experience. Material and methods: Medical documentation (812 persons, the period from 2008 to 2015), systematized and statistically processed. ET-1 and BNP were determined by enzyme immunoassay. The central hemodynamics was studied by the method of volumetric compression oscillometry. Results. A significant correlation was established between the prevalence of diseases of the cardiovascular system (CCC), work experience in harmful conditions, and the peculiarities of the production process, r = 0.36-0.44; r = 0.48-0.64; the development of respiratory pathology with the production process and experience, r = 0.52-0.61, r = 0.41-0.47. The structure of morbidity is mainly formed by respiratory diseases - from 5.7 % to 40%; the third rank place (7.8-10.0%) is occupied by CCC diseases. A number of the examined patients have combined cardiorespiratory pathology (CRP) - 42.4%. The changes are more typical for highly trained workers. The study revealed: an increase in the pulse wave velocity (p = 0.037); linear blood flow velocity (p = 0.029), a decrease in arterial compliance (p = 0.031) with an increase in peripheral vascular resistance (p = 0.031), signs of ED (increase in ET-1, BNP). Discussion. Changes in ET-1, BNP, elastic-elastic properties of the main vessels more often developed in highly trained workers. They manifested by the development of ED, occurring as an unfavourable factor in the early appearance and progression of bronchial obstruction followed by the formation of a chronic pulmonary heart, remodelling of the main vessels. Conclusion. The study of ED is an urgent problem for studying with the subsequent optimization of therapeutic and preventive measures at mining enterprises.