Native hypovitaminosis D (n-hVITD) is frequently found from the early stages of chronic kidney disease (CKD) and its prevalence increases with CKD progression. Even if the implications of n-hVITD in chronic kidney disease-mineral bone disorder (CKD-MBD) have been extensively characterized in the literature, there is a lot of debate nowadays about the so called “unconventional effects” of native vitamin D (25(OH)VitD) supplementation in CKD patients. In this review, highlights of the dimension of the problem of n-hVITD in CKD stages 2–5 ND patients will be presented. In addition, it will focus on the “unconventional effects” of 25(OH)VitD supplementation, the clinical impact of n-hVITD and the most significant interventional studies regarding 25(OH)VitD supplementation in CKD stages 2–5 ND.

In 178-kidney transplanted patients (KTxp), the prevalence of hypovitaminosis-D, the presence and novel development of left ventricular hypertrophy(LVH) and the correlations between native Vitamin-D (25OHD) and LVH were evaluated during the 1st year of transplantation (KTx). Clinical and instrumental data were recorded at pre-KTx and at one (T1) and 12 (T12) months after KTx. 25OHD levels were considered sufficient (s25OHD, ≥ 30 ng/dL) or insufficient (i25OHD, < 30 ng/dL). 25OHD correlated at T1 with parathormone(PTH), and at T12 with 25OHD-T1 and PTH-(T1,T12). At T12, s25OHD (15%) had higher 25OH and alkaline phosphatase (ALP), lower Ca, at T1, and lower PTH-(T1, T12) than i25OH-T12. At T1, KTxp with LVH (LVH-T1pos, 42%) were older and with longer dialysis vintage than LVH-T1neg. At T12, KTxp with LVH (LVH-T12pos, 53%) were older, with higher systolic blood pressure (SBP) at T12 than LVH-T12neg. No relation between 25OHD and LVH were found. Novel LVH was found in 14% of KTxp. They were older, had higher SBP-T12 and lower serum albumin-T12 than the others. LVH-modifications and 25OHD were not correlated. Hypovitaminosis-D is highly prevalent in KTxp. LVH correlates with different risk factors according to the time elapsed from KTx. However, during the 1st year of KTx, no relationship between LVH and 25OHD was observed.

Introduction and Aims: Renal osteodystrophy is a serious complication of chronic kidney disease (CKD) which leads to worsening of the quality of life, disability and increased mortality in patients with renal pathology. Therefore, further development of new methods of treatment in early stages of renal impairment is needed. The present study examined the safety and the effect of low-dose of alphacalcidol and strontium ranelate combined therapy on bone metabolism and bone density in pre-dialysis chronic renal failure patients with renal osteodystrophy. Methods: Subjects: 64 patients aged 21-67 years with mild to moderate chronic renal failure (creatinine clearance 30-89 ml/min), elevated parathyroid hormone (PTH) аnd serum cross-linked C-terminal telopeptide of type I collagen (s-CTx) concentration and reduced bone mineral density (BMD).

Background. Diabetic kidney disease (DKD) is

Матеріали Всеукраїнської науково-практичної конференції «Актуальні питання діагностики, лікування, раціональної фармакотерапії, диспансеризації та реабілітації в практиці сімейного лікаря» УДК 616. 61-036.12-78-06:616.447-007.6 DOI