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2 Городская клиническая больница № 2, Ставрополь, Российская Федерация 3 пятигорский межрайонный онкологический диспансер, Российская Федерация 4 первый Московский государственный медицинский университет им. И. М. Сеченова (Сеченовский университет), Российская Федерация 5 Дальневосточный государственный медицинский университет, Хабаровск, Российская ФедерацияPathological excess scar treatment is currently viewed as one of the most urgent issues with no single standard solution. We investigated the effectiveness of platelet-rich autoplasma use to stimulate wound healing. Seventy-six patients were assigned to two equivalent groups: control and main. The dynamics revealed a high efficiency of the plasma autostimulation method, which reduced the time of inpatient treatment, accelerated healing with a decrease in the effects of inflammation in the area of injury, stabilized angiogenesis, fibroplasia, and epithelialization, and, as a consequence, decreased the developmental rate of a pathological scar.

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A problem of optimizing the configuration of a navigation measuring system is considered in terms of the experimental design using a distance navigation problem for position of the object location. It is shown that the stated problem is equivalent to the problem of A-optimal experimental design for a regression function (nonlinear in parameters) and can be reduced to a trigonometric model. The response function, Fisher’s information and the sensitivity factor of the navigation system in case of two and three beacons and correlated measurements are presented in an explicit form. Using the equivalence theorem for A-criterion in the case of two-dimensional (plane) distance problem we confirm again the Barabanovs’s result that matrixes of A-optimal designs are the Kolmogorov – Maltsev matrixes. A similar result holds for the D-optimality criterion in the considered case. The effect of the measurement correlation in a distance navigation problem with two and three reference points is considered. The formulas for the sensitivity factors expressed in terms of bearings on the reference points and intersection angle of object are derived. In addition to a problem of optimizing the network configuration, the data processing problem in two-dimensional distance navigation problem with two reference points is also considered. The location of the object is determined in two ways, i.e., using the geometrical method and method of resultants. In the first method the solution of a distance navigation problem comes to the consideration of two independent quadratic equations for determination of the first and the second coordinates of the object. The equations are obtained in the explicit form. The second method also leads to two quadratic equations for determination of the object location. This is an option of the exclusion method which provides for an explicit form of conditions ensuring the solution of the considered problem for determination of the object location. Examples are considered that confirm the stated conclusions.

Aim. To assess adhesions of the abdominal cavity in children with varying degrees of connective tissue dysplasia (CTD) severity. Methods. A total of 91 children with average age of 10.6 1.4 years were observed from 2005 to 2019. Composed of 53 boys (58.2%) and 38 girls (41.8%). Patients were divided into two groups: group 1 (69 children without CTD) and group 2 (22 children with CTD). Clinical data and screening cards were used to diagnose DST. All patients underwent an assessment for the clinical course, a macroscopic visual assessment adhesive process severity in the abdominal cavity according to three different scales (Nair, F. Coccolini, N.I. Ayushinova). Immunohistochemistry was performed against collagen I, III, IV type, Laminin 1, angiogenesis factors, transforming growth factor beta (TGF-), and Fibroblast Growth Factor Receptor 1 (FGFR1). A semi-quantitative counting method was used to record the relative number of immunopositive structures. Statistical analysis was carried out by methods of variation statistics using the Chi-square test and MannWhitney U-tests, as well as the Spearman rank correlation method for the reliability of differences between groups. Results. In the adhesive process visualization, the N.I. Ayushinov scale was revealed to be the most informative, showing the average score of 7 0.8 points in group 2 and 14 1.2 in group 1 (rs 0.35; p 0.05). In group 2, the adhesive material showed no (56%) or chaotic fragments (44%) of type I collagen, and the ratio of type I to type III collagen is 2.7: 5.1. In group 1, the ratio of type I to type III collagen is 5.9:1.8. The ratio of collagen IV to type I is 6.5: 2.9. Both groups have a moderate (++) amount of TGF-. TGF- is positive with macrophages. FGFR1 was found in the control group (++++). A positive response was seen in fibroblasts and macrophages (U = 79.00; p = 0.006). Statistically significant analyzes of vascular endothelial growth factor in compared groups (rs = 0.632, p 0.001) had a positive correlation.. Conclusion. Thus, the study showed features of clinical course and morphological changes during the development of adhesions in the abdominal cavity in children with varying degrees of severity of CTD. Data obtained dictate the need for an individual approach in predicting adhesive disease, as well as targeted preventive care.