African leaf (Vernonia amygdalina) belongs to the Asteraceae family. Vernonia amygdalina is one of the plants that can be widely consumed and used in traditional medicine in Asia and Africa. This plant has been widely studied for its health benefits, so obtaining information about its phytochemical content and pharmacological activity is necessary. This article summarizes research data from 2012-2022 that reports on the review of phytochemicals and pharmacological activities of Vernonia amygdalina. This review collected data from Google Scholar, Research Gate, and NCBI . The results showed that the Vernonia amygdalina plant contains phytochemical compounds flavonoids, alkaloids, saponins, triterpenoids, steroids, cardiac glycosides, tannins, anthraquinones, and oxytocin.Various bioactive compounds in this plant are used as antifertility, antioxidant, anti-diabetic, anti-cancer, antipyretic, anti-inflammatory, anti-microbial, analgesic, and hypercholesterolemia. African leaves (Vernonia amygdalina) show various pharmacological activities related to the content of bioactive compounds as traditional medicine.