In most of the laboratory and occupational studies, Parkinson's syndrome (PS) is the major outcome of paraquat (PQ) toxicities. Nevertheless, the search for novel therapy against PS is still enormous. We therefore examined the effects of anti-inflammatory drugs against PS. Swiss mice (30-35g) were pretreated orally with saline, distilled water, acetylsalicylate acid (10mg/kg) or prednisolone (5mg/kg) for 7days. They were concurrently treated for another 5 weeks against intraperitoneal injection of 0.01ml and 0.02ml of (10mg/kg) PQ which were given twice a week to induced PS. Subsequently, movement deficits in mice were closely examined by using the spontaneous motor activity test, the catalepsy, and hanging tests. Thereafter, the mice brains were dissected for the biochemical tests. The data were analyzed using ANOVA, and the values were statistically significant at (p<0.0001, p<0.05). In conclusion, aspirin and prednisolone produced strong antioxidant effects that may be associated with change in the behavioral deficits.