The effect of a methanol extract of the stem bark of Entandrophragma angolense was investigated on indomethacin-induced gastric ulcer in rats. The effect of the extract was dose-dependent, doses ranging from 0.4 to 1.6 g/kg produced significant effect (p<0.05). At the highest dose used (1.6 g/kg) complete inhibition of ulceration occurred. The probable mechanism of action of E . angolense is discussed.
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