The article is devoted to the issues of the features of computer structural modeling of bio- and physiological systems of the human body. It has been established that most of the elements of a living organism and biological processes occurring in them are formalized using integral-differential equations of higher orders, the analytical solution of which is difficult. As modeling components of biotechnical systems and complexes, it is proposed to use circuitry implementation of a wide class of functional solvers based on functional circuits of operational amplifiers, which makes it possible to observe and study the dynamics of parameters of a biological object and bioprocesses in the visual modeling environment in the form of their mathematical models in real time.

Background: Vestibular schwannoma is a benign intracranial tumor of the vestibulocochlear nerve. Although it is a well-known pathology, growth factors and cytokine changes in vestibular schwannoma patients have not been totally elucidated. The objective of our study was to evaluate the concentration changes of transforming growth factor beta1, vascular endothelial growth factor, immunoglobulins A, M, and carcinoembryonic antigen in vestibular schwannoma patients. Methods: In our study, we performed an immunological analysis of 35 patients with vestibular schwannoma of different stages. According to the evolution of vestibular schwannoma, 20 patients did not show tumor growth, but 15 patients had a growing tumor. Results: The level of vascular endothelial growth factor in the blood serum of study groups exceeded the control values by 8 times and transforming growth factor beta1 by 1.65. Increased values of immunoglobulin A and immunoglobulin M were observed in patients with intracanal, second, and third stages of tumor, compared with the control group. Carcinoembryonic antigen was found to be of increased values in patients with intracanal and third-stage vestibular schwannoma, in comparison to the control group. Conclusion: Growth factors such as vascular endothelial growth factor and transforming growth factor beta1 can play a significant role in the genesis of vestibular schwannoma. In vestibular schwannoma patients, their investigation is appropriate both in the process of monitoring and in the assessment of treatment effectiveness. Immunoglobulins M and A can be used as additional markers of vestibular schwannoma, especially in tumor growth. Carcinogenic embryonic antigen has high values only in the late stages of vestibular schwannoma development.

The digital images quality estimating methods that are distorted by artifacts are considered. The most common types of artifacts are artifacts due to increased beam stiffness, the effect of partial volume filling, arbitrary patient movements during examination, etc. Quantitative and subjective measures are used to evaluate the quality of digital images. A comprehensive evaluation of the quality of tomographic images is proposed, based on the combination of the two above metrics, which will allow to better evaluate the quality of the tomographic image and to automate the evaluation process itself. A technique for evaluating the quality of tomographic images has been developed, which will allow for a more accurate diagnosis by eliminating the subjectivity of the physician.

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