Actuality. Three-dimensional (3D) printing (Construction 3D printing (c3Dp), 3D Construction Printing (3DCP), additive manufacturing) is an advanced manufacturing process that can produce construction component or buildings automatically from a 3D computer-aided design model [1]. To use 3D printing technology in construction, it is necessary to develop or improve mechanical equipment for 3D printing, development of mixtures and technological parameters of mortars, development of methods for controlling the physical and mechanical properties of materials, development of constructions of buildings and structures made by 3D printing. The purpose. The main objective of the presented research is to develop scientific bases and to create innovative architectural, structural and technological system of construction by 3D printing method of construction objects. Methodology. Engineering design has been applied to develop the mechanical equipment and structures made by 3D printing, laboratory study has been realized for development of mixtures and technological parameters of mortars, methods for controlling the physical and mechanical properties of materials. Finding. Theoretical and experimental studies were carried out at the SHEI PSACEA (Dnipro, Ukraine). Mechanical equipment for 3D printing was improved during the research. The developments were protected by patents of Ukraine. In the technological part of the research, compositions of mixtures with accelerating curing were developed. Concrete quality control methods were substantiated. The structural elements of buildings that are erected by 3D printing method are proposed and investigated. The results of the research were put into practice in construction. Scientific novelty and practical value. The results obtained are a significant contribution to the theory of technological innovation development, which make it possible to improve the efficiency of construction production while reducing the consumption of material and energy resources.