Background.In the previous studies, we compared the individuals who were almost identical to the average value of LF/HF ratio and its dispersion, but with opposite deviations from the norm of immunity. Two profiles of EEG have been created that reflect the differences between the two clusters. The first profile contains the parameters that in stress-sensitive individuals are in the zone of narrowed norm, whereas in stress-resistant individuals they are to some degree elevated, or at least exceed those in stress-sensitive individuals. The second profile contains EEG parameters, each of which in stress-resistant individuals is lower than that of stresssensitive individuals. The purpose of this study is to clarify the features of the HRV, endocrine and metabolic parameters in persons whose immune status is susceptible or resistant to chronic stress. Materials and Methods. The object of observation were 32 men and 8 women with chronic pyelonephritis in remission. The criterion for inclusion was the magnitude of the sympathico-vagal balance index LF/HF which exceeded the age norm by 0,5 σ. We determined spectral parameters of HRV, plasma levels of principal adaptation Hormones, plasma and daily urine levels of the Electrolytes and Nitrous metabolites as well as plasma Lipoproteines spectrum. Results. Discriminant analysis revealed that Testosterone is the main factor that conditioning the sensitivity of immune status to sympathotonic shift in autonomic regulation in chronic stress. Sensitizing (immunosuppressive) factors are also Ca/K-ratio of plasma and total Cholesterol, instead LD LP Cholesterol, Creatininuria, P/Ca-ratio of urine, spectral power of VLF band HRV as well as entropy of HRV are desensitizing (immunoprotective) factors. Conclusion.The susceptibility or resistance of the immune status to the stress sympathotonic shift of autonomic regulation is conditioned by the combination of EEG, HRV, endocrine and metabolic parameters.

Experimental and clinical physiology and biochemistry, ECPB 2019, 2(86): 11-23. https://doi.org/ hand, and HRV and EEG, on the other hand, as well as between changes in the immune and neural parameters caused by balneotherapy [15,16,17,18,19,20]. Hence, a hypothesis that, for the same states of the autonomic nervous system, the differences in immune responses to chronic stress were due to the features of the EEG. The verification of this hypothesis was the goal of this study. Material and methods. The object of observation were 32 men (aged 24-70 years old) and 8 women (39-71 years old) with chronic pyelonephritis in remission. The criterion for inclusion was the magnitude of the sympatho-vagal balance index LF/HF which exceeded the age norm by 0,5 σ.We recorded the electrocardiogram for 7 min in II group to assess the parameters of HRV [21,22] (software and hardware complex "CardioLab+HRV" produced by "KhAI-MEDICA", Kharkiv, Ukraine). For the further analysis the following parameters of heart rate variability (HRV) were selected. Temporal parameters (Time Domain Methods): the standard deviation of all NN intervals (SDNN), the square root of the mean of the sum of the squares of differences between adjacent NN intervals (RMSSD), the percent of interval differences of successive NN intervals greater than 50 ms (pNN 50 ). Spectral parameters (Frequency Domain Methods): spectral power density (SPD) bands of HRV: high-frequency (HF, range 0,4÷0,15 Hz), low-frequency (LF, range 0,15÷0,04 Hz), very low-frequency (VLF, range 0,04÷0,015 Hz) and ultra low-frequency (ULF, range 0,015÷0,003 Hz). Classical indexes were calculated: LF/HF, LFnu =100 %•LF/(LF+HF) and Baevskiy's Activity Regulatory Systems Index (BARSI) as well as the Entropy (h) of normalized SPD using CE Shannon's formula: hHRV = -[SPD HF•log 2 SPD HF + SPD LF•log 2 SPD LF + + SPD VLF•log 2 SPD VLF + SPD ULF•log 2 SPD ULF]/log 2 4. Experimental and clinical physiology and biochemistry, ECPB 2019, 2(86): 11-23. https://doi.org/

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