The paper presents the features of the development of endothelial dysfunction in workers under lead exposure. The results of laboratory manifestations of endothelial dysfunction have been demonstrated on the base of the study of parameters of vascular molecule of adhesion vCaM-1, soluble molecule of intercellular adhesion Sіcam-1, endothelin-1 in the blood of workers who professionally contact with lead. The features of formation of endothelial dysfunction, depending on the content of lead in the blood were identified. The thresholds for the studied parameters of endothelial dysfunction which are associated with high risk of atherosclerosis in this category of workers were determined.

The calculated indices such as leukocytic (LI), hematological (HI) and nuclear (NI) became the most commonly used in clinical practice to determine the endogenous intoxication. The aim of this study was to determine informativeness of the calculation methods for verification of the endogenous intoxication in workers depending on the content of lead in their blood. The calculated indices (nuclear, hematological and leukocyte) have been carried out in the blood of 146 workers exposure to lead, whose concentration in the air of the working area exceeded the maximum permissible concentration 1.4–1.8 times (study group) and 57 workers in the control group to study the parameters of endotoxemia. The index of reaction of a systemic response, sensitization index, an index of ratio between neutrophils and lymphocytes (IRNL) and an index of ratio between lymphocytes and eosinophils (IRLE) have been carried out in the blood sample of all workers to indicate the state of antitoxic adaptogenic system. The increase in Pb-K accompanied by statistically significant increase in the calculated indices of endogenous intoxication were detected for workers exposed lead. The endogenous intoxication characterized by changes in the calculated index leukocytic (LI), hematological (HI) and nuclear (NI) has been detected in workers exposed lead.

The aim: Diagnosis of bronchopulmonary pathology in the intensive care unit in patients with obstetric and gynaecological diseases and to implement aspects of the BLUE protocol in an intensive care unit for pregnant women with lung diseases. Materials and methods: The study involved pregnant women admitted to the intensive care unit at the city centre for reproductive medicine. To study the bronchopulmonary system, an Aloka 3500 ultrasound scanner was used, a chest X-ray was performed, spirometry study of the function of external respiration. Results: Identified radiological changes in the lungs that were confirmed by ultrasound. Data on changes in external respiration indices showed the presence of respiratory failure by restrictive type and was not accompanied by a change in the gas composition of the blood (SpO2 and EtCO2). Conclusions: technique for ultrasound examination of the bronchi-pulmonary system in pregnant women was developed and introduced in the intensive care unit. Ultrasound profiles of lung diseases were identified, which allow determining the intra and extrapulmonary changes in pregnant women in the early stages of pathology.

Introduction: Atherosclerosis is a trigger in the development of cardiovascular disease. Complications of atherosclerosis give reason to search for new criteria, diagnostic concepts, treatment methods and active preventive measures. The aim of our work is to study of the structural changes in the intima-media complex of the common carotid artery, pro-inflammatory cytokines (TNF-α, IL-6) secreted by mononuclear cells; the level of the intercellular adhesion molecule (according to sICAM-1), the level of the C-peptide of the blood, as well as the study of the relationship between these factors affecting the development of atherosclerosis. Materials and methods: In the group of 110 patients are studied the levels of secretion of TNF-α, IL-6, the soluble intercellular adhesion molecule-1, the level of blood C-peptide, performed of duplex scanning of the brachiocephalic vessels, studied of biopsy of the skin. Results and conclusions: In the group of patients with atherosclerosis and the accompanying metabolic syndrome, endothelial activation is noted under the influence of risk factors (hyperinsulinemia, arterial hypertension, hypercholesterolemia), accompanied with the activation of mononuclear cells (with marked hyperproduction of proinflammatory cytokines (IL-6) and thickening of the intima-media complex of the common carotid artery with an increase in body weight. Patients with metabolic syndrome develop microangiopathy (edema of endothelial cells, thickening and reduplication of the basement membranes, focal reaction of the pericytes).