The scientific literature presents quite a large number of works, in which the priority role of mathematical modeling in providing high-quality medical care, health and active longevity of a person is determined. The purpose of the work is to construct and analyze the regression models of individual sonographic sizes of kidneys in practically healthy women of the middle intermediate somatotype, depending on the features of the anthropometric and somatotypological indicators. Within the framework of the agreement on scientific cooperation from the database of National Pirogov Memorial Medical University, Vinnytsya primary sonographic parameters (length, width, anterior-posterior dimension, area of longitudinal and cross-section of the kidneys and their sinuses, as well as volume of the right and left kidneys) and anthropometric indices (obtained by the method of V.V. Bunak in the modification of P.P. Shaparenko) of 17 practically healthy women of the first mature age of the middle intermediate somatotype, who in the third generation live in the Podillya region of Ukraine. The construction of regression models of individual sonographic sizes of the kidneys, depending on the features of anthropo-somatotypological parameters of the body of women of the middle intermediate somatotype, was carried out in the licensed package “Statistica 6.1”. In women of the middle intermediate somatotype all 16 possible reliable regression models of sonographic parameters of the kidneys were constructed depending on the anthropo-somatotypological parameters with the determination coefficient R2 from 0.891 to 0.978. The analysis of reliable regression models (with a coefficient of determination greater than 0.6), the sonographic parameters of the kidneys in practically healthy women of the middle intermediate somatotype revealed that most often models of both kidneys, as well as separately of the right and left kidneys, include the circumferential dimensions of the body (respectively, 35.9 – 33.3 – 38.5% of the total number of indicators included in the models). In addition, models of both kidneys most often include cephalometric indices (12.6%), thickness of skin-fat folds and body diameters (by 11.7%); models of the right kidney – body diameters (15.7%), cephalometric indices and width of distal epiphyses of long tubular bones of extremities (by 11.8%); models of the right kidney - the thickness of skin and fat folds (17.3%) and cephalometric indices (13.5%). Attention is drawn to the lack of entry into models of sonographic sizes of kidneys total body sizes.

The application of the mathematical method for establishing quantitative relationshipsbetween the set of anthropometric parameters and sonographic parameters of thepatient allows in some cases to significantly improve early diagnosis of diseases, makeit not only timely, but accurate. The purpose of the work is to analyze the regressionmodels of individual sonographic sizes of the kidneys in practically healthy men andwomen of the endo-mesomorphic somatotype, depending on the peculiarities of thestructure and size of the body. Sonographic renal research conducted using ultrasonicdiagnostic system "CAPASEE" SSA-220A (Toshiba, Japan). For each kidney, the length,width (transverse size) and front and rear dimensions were determined; the area of thelongitudinal and transverse sections of the kidneys and their sinuses, as well as thevolume of the right and left kidneys. All of them had an anthropometric survey conductedby V.V. Bunak in the modification of P. P. Shapаrenko. The evaluation of thesomatotype was carried out according to the mathematical scheme of J. Carter and B.Heath. Determining the absolute amount of fat, bone and muscle components of bodyweight was calculated by the formula J. Matiegka and the muscular component - bythe formulas of the American Institute of Nutrition. For the construction of models ofindividual sonographic parameters of the kidneys, the method of stepwise regressionanalysis in the package "STATISTICA 6.1" was used. In practically healthy men andwomen of Podillia endo-mesomorphic somatotype of 16 possible 14 reliable regressionmodels of sonographic parameters of the right and left kidneys, based on anthropo-somatotypological indicators with a determination coefficient, from 0.767 to 0.966 andfrom 0.672 to 0.912 were constructed. The constructed models of sonographicparameters of both kidneys in men endo-mesomorphic somatotype most often includethe circumferential body dimensions (22.4%), cephalometric indices and the thicknessof skin and fat folds (17.1%), body diameters (14.5%), and longitudinal body dimensions(11.8%). The constructed models of sonographic parameters of both kidneys in womenendo-mesomorphic somatotype most often include circumferential body sizes (23.1%),body diameters (20.5%), cephalometric indices (19.2%) and thickness of skin and fatfolds (16.7%). In the analysis of entering into models of sonographic parameters of thekidneys anthropometric and somatotypological indicators, expressed manifestations ofasymmetry and sexual dimorphism

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The study of the constitutional features of organs in the healthy population makes it possible to find out the peculiarities of changes in their sizes in different pathologies. The purpose of the work is to construct and analyze the regression models of individual sonographic sizes of the kidneys in practically healthy women of the ectomorphic somatotype, depending on the features of anthropo-somatotypological parameters of the body. From the database of research center of the National Pirogov Memorial Medical University, Vinnytsya (within the framework of the agreement on scientific cooperation) were taken the primary sonographic parameters (length, width, front and rear size, area of the longitudinal and cross section of the kidneys and their sinuses, as well as the volume of the right and left kidneys) and anthropometric indices (according to V. V. Bunak in the modification of P. P. Shapаrenko) of practically healthy women-ectomorphs of the first mature age, who in the third generation live in the Podillia region of Ukraine. Regression models of individual sonographic sizes of the kidneys, depending on the features of anthropo-somatotypological parameters of the body, are constructed using the license package “Statistica 6.1”. In practically healthy women of the ectomorphic somatotype all 16 possible reliable regression models of sonographic parameters of the right and left kidneys, based on the anthropometric and somatotypological parameters with determination coefficient R2 from 0.607 to 0.973, were constructed. Constructed regression models of sonographic parameters of both kidneys in practically healthy women of the ectomorphic somatotype most often include body diameters (24.2% of the total number of indicators included in the models), circumferential body sizes (20.9%), cephalometric indices (19.8 %) and the thickness of skin and fat folds (14.3%). The regression models of sonographic parameters of the right kidney in women of the ectomorphic somatotype most often include diameters and circumferential body sizes (by 27.3% of the total number of indicators included to the models of right kidney) and cephalometric indices (18.2%). The regression models of the sonographic parameters of the left kidney in women of the ectomorphic somatotype most often include body diameters and cephalometric indices (by 21.3% of the total number of indices included to the models of the left kidney) and the circumferential body size and thickness of skin and fat folds (by 14.9%).

Introduction: In the treatment of hypothyroidism substitution therapy with L-thyroxine is used, it is also advisable to use the metabolites with membrane-stabilizing properties that normalize the metabolism in the body, for example, calcitonin, which significantly reduces the depth of the dystrophic phenomena in the myocardium. The aim was to study the patterns of structural changes in the left ventricular myocardial capillaries of rats with congenital hypothyroidism in combinative drug therapy with L-thyroxine and calcitonin. Materials and methods: 30 white Wistar line rats were used as experimental animals: 10 with treatment and 10 without as well as control – 10 intact Wistar line rats of the same age. Mercazolil was used to inhibit thyroid gland in order to model congenital hypothyroidism. After birth, the rats received L-thyroxine at a dose of 10 μg / kg per os daily, calcitonin at a dose of 1.0 MU / kg per day intramuscularly, then with mother’s milk, later by themselves for 100 days. The arterial pressure was measured in all experimental groups during extraction from the experiment by plethysmograph, their left ventricular myocardium was examined under electron microscope and micropinocytotic vesicles in their cells were studied morphometrically. Results: In rats with congenital hypothyroidism, for which L-thyroxin drug in combination with calcitonin was used as a substitution therapy, after pharmacological correction, in general there is no pronounced heteromorphism of the ultrastructure of the left ventricular myocardial blood capillaries, which was characteristic for animals without pharmacological correction. The analysis showed normalization of the content of free thyroxine in blood plasma and blood pressure of rats with congenital hypothyroidism after complex substitution therapy. Conclusions: In rats with congenital hypothyroidism, which received L-thyroxine and calcitonin at birth, the myocardium capillaries generally remain intact and have morphological and functional characteristics similar to intact animals, which is the theoretical basis for the need for calcitonin to be used in substitution therapy in hypothyroidism.