Introduction. The social significance of occupational dust pathology is due to its leading position in the structure of mortality from occupational diseases. Stress tests are an important stage in a comprehensive approach to assessing and predicting the health status of trained dust workers. The aim of study was to study the relationship between exercise tolerance and the state of the cardiorespiratory system in employees of dust-hazardous professions based on the results of a 6-minute walking test (6MW). Materials and methods. Using data from echocardiography, spirometry, bodyplethysmography (BPG), a 6MW test and simultaneous monitoring of blood oxygen saturation (SpO2), 193 working dust professions (DP) (79 people), chronic obstructive pulmonary disease (COPD) (56 people) and patients without signs of respiratory pathology (58 people) were examined. Results. The peculiarities of spirometry and BPG, traced the relationship of load test results with the results of functional studies of cardio-respiratory status. Conclusions. It was found that SpO2 in the dynamics of the 6mx test shows a different relationship with spirometry indicators, characterizing the main pathogenetic moments of the formation of respiratory failure.

The influence of aerosols of fibrogenic action on the state of the cardiorespiratory system in dust-hazardous industries does not lose its significance over the years since the pathology of the respiratory organs gradually develops in working-age workers. Continuous medical monitoring of the health status of the working population, improvement of diagnostic research methods and their application at the early stages of exposure to harmful industrial factors will help prevent the development of occupational diseases and preserve the ability to work professional aptitude. Objective. To study the relationship between the state of the cardiorespiratory system and exercise tolerance based on the results of a 6-minute walk test in patients with dust pathology of the respiratory organs. Material and methods. 193 men with confirmed pneumoconiosis (79 people), occupational chronic obstructive pulmonary disease (58 people) and those in contact with the dust factor at work without respiratory pathology (56 people) were examined using echocardiography, spirometry, bodyplethysmography, a 6-minute walking load test with simultaneous monitoring of blood oxygen saturation (saturation) and pulse. Results. The correlation of the results of the 6-minute test with the functional state of the cardiorespiratory system of the subjects was revealed. The oxygen saturation of the blood during the exercise test was confirmed to show a different relationship with the indices of bodyplethysmography and spirometry, characterizing the central pathogenetic moments of the formation of respiratory failure. Conclusion. characteristic changes in saturation during the test with a 6-minute walk make an accessible and at the same time significant contribution to the diagnosis of respiratory organs in workers of dust-hazardous occupations.

Introduction. The development of ferruginous quartzites of the Kursk magnetic anomaly basin is accompanied by the release of dust, which affects miners. Identification of markers of preclinical pathology of the cardiorespiratory system (CRS) is relevant. Objective is to identify markers of endothelial dysfunction (ED) (endothelin-1 (ET-1), brain natriuretic peptide (BNP), changes in the elastic properties of blood vessels) at the preclinical stage of the development of pathology of the cardiovascular system and pathology of the respiratory organs in workers of dust occupations with different experience. Material and methods: Medical documentation (812 persons, the period from 2008 to 2015), systematized and statistically processed. ET-1 and BNP were determined by enzyme immunoassay. The central hemodynamics was studied by the method of volumetric compression oscillometry. Results. A significant correlation was established between the prevalence of diseases of the cardiovascular system (CCC), work experience in harmful conditions, and the peculiarities of the production process, r = 0.36-0.44; r = 0.48-0.64; the development of respiratory pathology with the production process and experience, r = 0.52-0.61, r = 0.41-0.47. The structure of morbidity is mainly formed by respiratory diseases - from 5.7 % to 40%; the third rank place (7.8-10.0%) is occupied by CCC diseases. A number of the examined patients have combined cardiorespiratory pathology (CRP) - 42.4%. The changes are more typical for highly trained workers. The study revealed: an increase in the pulse wave velocity (p = 0.037); linear blood flow velocity (p = 0.029), a decrease in arterial compliance (p = 0.031) with an increase in peripheral vascular resistance (p = 0.031), signs of ED (increase in ET-1, BNP). Discussion. Changes in ET-1, BNP, elastic-elastic properties of the main vessels more often developed in highly trained workers. They manifested by the development of ED, occurring as an unfavourable factor in the early appearance and progression of bronchial obstruction followed by the formation of a chronic pulmonary heart, remodelling of the main vessels. Conclusion. The study of ED is an urgent problem for studying with the subsequent optimization of therapeutic and preventive measures at mining enterprises.