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NEURO-ONCOLOGY • NOVEMBER 2017 for hypermutated gliomas using a radiomics-based approach. MATERIALS AND METHODS: We retrospectively analyzed a total of 97 patients with primary gliomas from the University of Texas MD Anderson Cancer Center. Mutation status was determined post-biopsy (stereotactic/excisional) using Next Generation Sequencing (T200 and Foundation 1), and patients were grouped based on their mutation burden; 77 hypomutated (<30 mutations) and 20 hypermutated (>=30 mutations or <30 with MMR gene mutations). Radiomic analysis was performed on the conventional MR images (FLAIR and T1 post-contrast) obtained prior to tumor tissue surgical sampling; and a total of 2480 rotation-invariant radiomic features were extracted using: (i) the first-order histogram and (ii) grey level co-occurrence matrix. The Maximum Relevance Minimum Redundancy technique was used to select the most relevant radiomic features. ROC analysis and leave-one-out cross-validation (LOOCV) were used to assess the performance of the Support Vector Machine (SVM) classifier and AUC, Sensitivity, Specificity, and p-value were obtained. RESULTS: We found 100 radiomic features that can discriminate between hypermutated versus hypomutated gliomas, AUC 100% (CI: 96%-100%), Sensitivity 100%, Specificity 100%, p-value=1.8e-10. CONCLUSION: Increase in mutation burden seen in post-treatment glioma samples is associated with a unique radiomic texture signature on pre-sampling MRI and can be used to predict mutation burden status non-invasively.

18/ Том XXIII / 2 3. Dubossarskaya Y, Dubossarskaya Z. [Syndrome of chronic pelvic pain at the level of cross-disciplinary communication]. Meditsinskie aspekty zdorov'ya zhenshchiny. 2013;3(67):5-16. Russian. 4. Radzinskiy VE., editor. [Women`s consultation: practice manual]. Moskva, GEOTAR-Media; 2009. Russian. 5. Zaporozhchenko MВ. [The combination of leiomyoma and endometriosis in women of reproductive age]. Reproduktivnaya endokrinologiya, 2017;4(36):24-29. Russian. 6. Adamyan LV, editor. [Clinical recommendations for managing patients "Combined benign diseases of the uterus (myoma, adenomyosis, endometrial hyperplasia)"]. Moskva, Clinical guidelines; 2015. Russian. 7. Kuznetsova IV. [Chronic pelvic pain]. Akusherstvo i ginekologiya. 2013;5:91-97. Russian. 8. [The modern approaches to the surgical and postsurgical medicamental management of patients with endometriosis. Resolution of the expert council]. Reproduktivnaya endokrinologiya, 2017;2:8-10. Ukrainian. 9. Harchenko YuA. [Adequate assessment of pain is the pledge of successful treatment]. "Universum: Medicine and Pharmacology". [Internet]. 2014;4(5).

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