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The total synthesis of μ-conotoxin lt5d is presented for the first time employing two different strategies.

Nobilamide B, a TRPV1 antagonist, and a series of Ala-substituted analogues were synthesized and their neuroactivity was assessed in a primary culture of dorsal root ganglion (DRG) neurons.

A novel methodology involving the use of Gd3+–Xylenol Orange (Gd–XO), a solution colorimetric probe, was used to determine the conditional relative rates of complex formation between the Gd3+ ion and polyamino carboxylate ligands used in MRI contrast agent development. Among the ligands tested, the order of rate of Gd‐complex formation was found to be DTPA ≈ DOTP > DOTA > DO3A > DOTAM. The observed rates are an effect of ligand denticity, backbone structure, and nature of the ligand donor groups.