No abstract

A concise one-pot route for the synthesis of 2,3-dihydroisoxazoles via a dual gold-iron catalysis has been devised. The method, based on the addition of binucleophilic protected hydroxylamine to propargylic alcohols, enables a one-pot, highly selective synthesis of these heterocycles (10 examples, up to 86% yield).

SummaryThis personal account summarizes our recent developments in gold-catalyzed direct substitutions on propargylic (allylic, benzylic) alcohols, with various nucleophiles (and bi-nucleophiles) based on the σ- and/or π-acidity of gold(III) complexes. Synthetic developments are also briefly described.