Effects of radiation in biological systems are quite interesting. Interaction of radiation to epigenetic mechanisms has been also demonstrated earlier. The aim of this review is to sketch a current scenario on radiation exposure/insults on the epigenetic mechanisms in mammalian cells. Evidence from the databases, mainly from Pubmed and Science Direct were considered. Findings suggest that radiation has a dose and time-dependent effect in our body. Cells and tissues from different sources have differential responses towards radiation insults. Although radiation has impacts on epigenetic modulation, but it has beneficial combinatorial effects with a number of epigenetic modalities. Radiation has both bad and good impacts on epigenetic mechanisms.

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