Background: Silver nanoparticles (SNP) are the most preferred and most often used metallic nanoparticles in biomedical studies. However, there are only few studies on its application in topical drug delivery design. Objectives: This study was carried out to design topical ointments containing n-hexane and methanol Ehretia cymosa leaf extracts mediated-silver nanoparticles for the treatment of inflammation.Methods: Silver nitrate was reacted with n-hexane and methanol extracts of Ehretia cymosa leaf to synthesize SNP  used in the formulation of an ointment. The SNP was characterized by visual observation, UV–visible spectroscopy,  atomic absorption spectroscopy and FTIR spectroscopy. The physical characteristics of the ointment and  spreadability were evaluated. Inflammation was inflicted by carrageenan-induced paw acute edema  method in albino  rats. The linear paw circumference was measured hourly after application of the ointment.Results: There was colour change as the synthesis progresses. The absorption peak of n-hexane SNP (N-SNP) and methanol SNP (M-SNP) was 450 nm and 430 nm respectively. The ointments were easy to administer with satisfactory spreadability but difficult to wash off. Ointments containing SNP had significantly higher activity (p < 0.05) than the crude extract and ointments containing M-SNP had significantly higher activity (p < 0.05) than ointments containing N-SNP.Conclusion: The anti-inflammatory activity of ointment containing SNP synthesized with methanol extract is significantly higher compared to ointment formulations containing silver nanoparticle synthesized with n-hexane extract and the reference drug (diclofenac).