Background: The progress in the use of computer-aided design/computer aided manufacturing (CAD/CAM) to fabricat removable prosthodontic prostheses in dental clinics has been exponential. Commercially existing CAD/CAM denture techniques grow every year with increasing benefits to dentists and patients. Study Design: Systematic review. Aims: This review assessed and evaluated the different clinical production protocols of presently accessible CAD/CAM denture systems that offer decision support for dental practitioners. Methodology: Data   for the current object were collected by surveys from different companies manufacturing the Computer Engineering Complete Denture (CECDs). All related subjects published at the last 10 years were collected and included in this review. Techniques were arranged in alphabetical order, as follows. AvaDent Digital Dentures (Global Dental Science), Baltic Denture Creator System (Merz Dental GmbH), and Ceramill Full Denture System (Amann Girrbach AG) can manufacture denture fabrication in three visits, including a try-in step. DENTCA Digital Dentures (Whole You Nexteeth, Inc) can also perform this in three visits. The Wieland Digital Denture (Ivoclar Vivadent, Inc) can manufacture in four dental appointments. Recently developed VITA VIONIC Digital System (VITA Zahnfabrik, Bad Säckingen, Germany) can perform two-step CECD manufacturing. Results: Most of the systems involved subtractive manufacturing for the fabrication of their dentures and only closed systems. However, Baltic Denture System and VITA VIONIC material types are an open structure that allow users to choose among different handling protocols. It can be shared with several unclosed digital scanner, CAD software options, and milling machines. Conclusions: The six existing CECD fabrication systems offer many advantages. The decision on which technique to use may be contingent on the dentist’s prosthodontic expertise, patient output amount, and requirements concerning denture individualization.