The purpose of this study was to identify the relationship between spiritual well-being, perceived social support, and life satisfaction among the university students in Jordan. A cross-sectional descriptive-correlation design was used to carry out on a convenience sample of 919 students at the University of Jordan. University students reported moderate levels of both spiritual well-being and perceived social support, and they were slightly satisfied with their lives. Significant positive correlation was found between spiritual well-being with perceived social support and life satisfaction (r = .49, .53, p < .001) respectively, and positive correlation was found between perceived social support and life satisfaction (r = .46, p < .001). Both domains of spiritual well-being had significant positive correlation with all sources of perceived social support. The relationships between spiritual well-being and perceived social support should be considered in university health programs. Study implications and recommendations were discussed.